Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Isomerase
Patent
1987-08-11
1991-08-20
Teskin, Robin L.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Isomerase
435 691, 435 712, 435 91, 435169, 4351723, 4352523, 4353201, 435886, 536 27, 935 14, 935 29, 935 61, 935 72, C12N 992, C12N 1509, C12N 1552
Patent
active
050413783
ABSTRACT:
Xylose isomerase (XI) muteins useful in the conversion of glucose to fructose or xylose to xylulose are obtained in usable amounts by protein structural and recombinant DNA methods, including x-ray crystallography, cloning, computer graphic modeling and site-directed mutagenesis and expression of the bacterial DNA sequences encoding native procaryotic xylose isomerase. These native sequences are altered to encode the xylose isomerase muteins having improved catalytic function and/or thermostability.
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Bloch Will
Drummond Robert J.
Matthews Brian W.
Toy Pamela L.
Cetus Corporation
Mendel SaraLynn
Peet Richard C.
Teskin Robin L.
Univerity of Oregon
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