Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Alkali or alkaline earth chloride
Patent
1992-09-25
1994-02-01
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Alkali or alkaline earth chloride
424697, 514249, 514356, 514392, 514474, 514537, A61K 3314, A61K 3306, A61K 31495, A61K 3144, A61K 3134, A61K 3124
Patent
active
052830683
ABSTRACT:
A procaine acid addition salt, wherein the acid is attached to the diethylamino nitrogen, is complexed with a biologically active organic acid such as a vitamin acid, essential unsaturated fatty acid, C.sub.4 to C.sub.6 hydroxycarboxylic acid or alpha amino acid in stoichiometric ratios of organic acid to procaine acid addition salt to form a double salt complex wherein the organic acid attaches to the p-amino nitrogen. Such double salt complexes protect the procaine molecule from cholinesterase hydrolysis when orally administered to warm blooded animals allowing the complex to be carried intact to the site of damaged cells and across the cell membrane where the double salt complex is disassociated in the cell releasing the organic acid and procaine for cellular repair and regeneration. Procaine hydrochloride is the preferred procaine salt. Preferred acids are citric and vitamin acids including nicotinic acid, ascorbic acid, biotin and folic acid.
REFERENCES:
patent: 4010193 (1977-03-01), Harsanyi et al.
patent: 4956391 (1990-09-01), Sapse
patent: 5064858 (1991-11-01), Sapse
Henley III Raymond J.
Waddell Frederick E.
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