Procaine double salt complexes

Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Alkali or alkaline earth chloride

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Details

424697, 514249, 514356, 514392, 514474, 514537, A61K 3314, A61K 3306, A61K 31495, A61K 3144, A61K 3134, A61K 3124

Patent

active

052830683

ABSTRACT:
A procaine acid addition salt, wherein the acid is attached to the diethylamino nitrogen, is complexed with a biologically active organic acid such as a vitamin acid, essential unsaturated fatty acid, C.sub.4 to C.sub.6 hydroxycarboxylic acid or alpha amino acid in stoichiometric ratios of organic acid to procaine acid addition salt to form a double salt complex wherein the organic acid attaches to the p-amino nitrogen. Such double salt complexes protect the procaine molecule from cholinesterase hydrolysis when orally administered to warm blooded animals allowing the complex to be carried intact to the site of damaged cells and across the cell membrane where the double salt complex is disassociated in the cell releasing the organic acid and procaine for cellular repair and regeneration. Procaine hydrochloride is the preferred procaine salt. Preferred acids are citric and vitamin acids including nicotinic acid, ascorbic acid, biotin and folic acid.

REFERENCES:
patent: 4010193 (1977-03-01), Harsanyi et al.
patent: 4956391 (1990-09-01), Sapse
patent: 5064858 (1991-11-01), Sapse

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