Probing of specific nucleic acids

Details Probing of specific nucleic acids Probing of specific nucleic acids

2008-04-01

2008-04-01

Forman, B J (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C435S287200, C536S023100, C536S024300

Reexamination Certificate

active

10029913

ABSTRACT:
The present invention relates to improved methods for probing of specific nucleic acids using circularizable probes designed such that they report the presence of a target sequence by allowing a detectable moiety to remain bound if an only if the probe has been cyclized in a target-dependent linking reaction. The invention may be used for distinction between sequence specific variations of nucleic acids.

REFERENCES:
patent: 5124246 (1992-06-01), Urdea
patent: 5427930 (1995-06-01), Birkenmeyer
patent: 5643724 (1997-07-01), Fildes
patent: 5871921 (1999-02-01), Landegren
patent: 5952176 (1999-09-01), McCarthy et al.
patent: WO 95/22623 (1995-08-01), None
Nilsson et al., “Padlock Probes: circularizing oligonucleotides for localized DNA detection”, Science, (Sep. 30, 1994), vol. 265, pp. 2085-2088.
Nilsson et al. “Padlock probes: Circulating oligonucleotides for localized DNA detection”, Science vol. 265, pp. 2085-2088.
Stratagene catalog, p. 39.

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