Probes for the detection of nucleotide sequences implicated in t

Details Probes for the detection of nucleotide sequences implicated in t Probes for the detection of nucleotide sequences implicated in t

1994-08-05

1999-02-16

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 2432, 536 2433, C12Q 168, C12P 1934, C07H 2104

Patent

active

058719105

ABSTRACT:
The invention relates to isolated polynucleotides and probes which are optionally labelled and which hybridize with polynucleotides encoding polypeptides implicated in the bacterial resistance to vancomycin, teicoplanin and to both vancomycin and teicoplanin. The invention also relates to the utilization of these polynucleotide probes for the diagnosis of resistance to the glycopeptides.

REFERENCES:
Mol. Gen. Genet., vol. 224, No. 3, Dec. 1990, Springer Verlag, S. Dutka-Malen et al.: The VANA Glycopeptide Resistance Protein is Related to D-alanyl-D-alanine Ligase Cell Wall Biosynthesis Enzymes, pp. 364-372.
Biochemistry, vol. 30, No. 8, 26 Fevrier 1991, American Chemical Society: T.D.H. Bugg et al.: "Identification of Vancomycin Resistance Protein VanA as a D-alanine: D-alanine Ligase of altered Substrate Specificity", pp. 2017-2021.
Antimicrobian Agents and Chemotherapy, vol. 34, No. 5, May 1990, American Society for Microbiology; A. Brisson-Noel et al.:"Cloning and heterospecific expression of the resistanc determinant vanA encoding high-level resistance to glycopeptides in Enterococcus faecium BM4147", pp. 924-927.
Antimicrobian Agents and Chemotherapy, vol. 34, No. 10, Oct. 1990, American Society for Microbiology; S. Dutka-Malen et al.: "Phenotypic and genotypic heterogeneity of glycopeptide resistance determinants in Gram-positive bacteria", pp. 1875-1879.
Antimicrobian Agents and Chemotherapy, vol. 33, No. 2, Janvier 1989, American Society for Microbiology; R. Leclercq et al.: Transferable vancomycin and teicoplanin resistance in Enterococcus faecium:, pp. 10-15.
Robinson et al., J. Bacteriol. 167(3), 809-817 (1986).
Daub et al., Biochemistry 27, 3701-3708 (1988).
Varshney et al., J. Biol. Chem. 263(16), 7776-7784 (1988).
Arthur et al., Gene 103, 133-134 (1991).

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