Probes for and nucleic acid encoding the muscular dystrophy prot

Details Probes for and nucleic acid encoding the muscular dystrophy prot Probes for and nucleic acid encoding the muscular dystrophy prot

1995-03-17

1997-04-15

Walsh, Stephen G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2431, C12N 1511, C07H 2104

Patent

active

056210914

ABSTRACT:
The invention relates to a muscular dystrophy (MD) probe comprising a substantially purified single-stranded nucleic acid sequence capable of hybridizing to a region of DNA on a human X chromosome between the deletion break point at Xp21.3 and the translocation break point at X;11. The invention also relates to a 14 kb cDNA corresponding to the complete MD gene and probes produced therefrom useful in genetic methods of diagnosis of MD. Furthermore, the invention relates to the polypeptide, dystrophin, which corresponds to the MD gene product, and antibodies thereto that are useful in a variety of methods for immunodiagnosis of MD.

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