Probes comprising modified adenine groups, their preparation and

Details Probes comprising modified adenine groups, their preparation and Probes comprising modified adenine groups, their preparation and

1985-08-22

1989-06-27

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 26, 536 27, 935 77, 935 78, C12Q 168

Patent

active

048429961

ABSTRACT:
The invention relates to a probe constituted by an oligonucleotide fragment of structure predetermined by the application envisaged, wherein at least a part of the adenine groups therein is replaced by modified adenine groups so that they can form three hydrogen bonds with the reactive groups of thymine or uracil. This probe is useful in the field of biological analyses and extractions.

REFERENCES:
patent: 4556643 (1985-12-01), Paau
patent: 4563417 (1986-01-01), Albanella
Chemical Abstracts, vol. 94, No. 13, p. 232, No. 97632j (Mar. 30, 1981).
Kirnos, Chemical Abstracts, 88:101277t.
Gaffney--I, Nucleic Acids Research, 10(4), pp. 4351-4361 (1982).
Gaffney--II, Tetrahedron, 40(1), pp. 3-13 (1984).

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