Probes and methods for detecting activated ras oncogenes

Details Probes and methods for detecting activated ras oncogenes Probes and methods for detecting activated ras oncogenes

1985-07-23

1989-10-03

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

935 78, 935 9, 435 6, 435803, 436813, C07H 2100, C12Q 168

Patent

active

048718386

ABSTRACT:
Molecules complementary to nucleotide sequences encoding mutant ras protiens which contain a single-base mutation in the codon encoding amino acids at position 13, 12 or 61 have been produced. These molecules are useful in methods of detecting specific single-base mutations in altered ras genes and the specific cancers associated with such mutations.

REFERENCES:
patent: 4535058 (1985-08-01), Weinberg et al.
patent: 4725550 (1988-02-01), Perucho et al.
Guerrero, I. et al., Science, vol. 225, 1984, pp. 1159-1162.
Zarbl, H. et al., Nature, vol. 315, 1985, pp. 382-385.
Guerrero, I. et al., Proc. Natl. Acad. Sci. USA, vol 81, 1984, pp. 202-205.
Studencki, A. B. et al., DNA, vol. 3, 1984, pp. 7-15.

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