Probe-antiprobe compositions and methods for DNA or RNA...

Details Probe-antiprobe compositions and methods for DNA or RNA... Probe-antiprobe compositions and methods for DNA or RNA...

2007-08-15

2011-12-13

Whisenant, Ethan C (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091200, C536S022100, C536S023100, C536S024300

Reexamination Certificate

active

08076067

ABSTRACT:
The invention provides novel compositions and methods for detecting unlabeled nucleic acid targets using labeled polynucleotide probes and partially complementary antiprobes. The interaction of probes, antiprobes and targets result in signaling changes that indicate target frequency. This novel detection mechanism is called a DNA detection switch, and it enable end-point detection, microarray detection and real-time PCR detection of a variety of nucleic acid targets including microbial species and subspecies, drug resistant mutants, and pathogenic strains.

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