Probe and apparatus for desorption and ionization of analytes

Details Probe and apparatus for desorption and ionization of analytes Probe and apparatus for desorption and ionization of analytes

2006-02-03

2008-11-11

Alexander, Lyle A (Department: 1797)

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Means for analyzing liquid or solid sample

C250S287000, C436S173000, C436S174000, C436S178000

Reexamination Certificate

active

07449150

ABSTRACT:
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.

REFERENCES:
patent: 3896661 (1975-07-01), Parkhurst et al.
patent: 4022876 (1977-05-01), Anbar
patent: 4295046 (1981-10-01), Gruter et al.
patent: 4296332 (1981-10-01), Hill
patent: 4454233 (1984-06-01), Wang
patent: 4468468 (1984-08-01), Benninghoven et al.
patent: 4665192 (1987-05-01), Cerami
patent: 4686366 (1987-08-01), Stuke
patent: 4694167 (1987-09-01), Payne et al.
patent: 4705616 (1987-11-01), Andresen et al.
patent: 4902627 (1990-02-01), Kidwell
patent: 4988879 (1991-01-01), Zare et al.
patent: 5003059 (1991-03-01), Brennan
patent: 5045694 (1991-09-01), Beavis et al.
patent: 5073713 (1991-12-01), Smith et al.
patent: 5078135 (1992-01-01), Caprioli
patent: 5118937 (1992-06-01), Hillenkamp et al.
patent: 5124267 (1992-06-01), Humpel et al.
patent: 5171989 (1992-12-01), Williams et al.
patent: 5209919 (1993-05-01), Turteltaub et al.
patent: 5260571 (1993-11-01), Cottrell et al.
patent: 5317932 (1994-06-01), Westlake, III et al.
patent: 5547835 (1996-08-01), Koster
patent: 5605798 (1997-02-01), Koster
patent: 5622824 (1997-04-01), K oster
patent: 5719060 (1998-02-01), Hutchens et al.
patent: 5894063 (1999-04-01), Hutchens et al.
patent: 6020208 (2000-02-01), Hutchens et al.
patent: 6027942 (2000-02-01), Hutchens et al.
patent: 6060237 (2000-05-01), Nygren et al.
patent: 6124137 (2000-09-01), Hutchens et al.
patent: 6225047 (2001-05-01), Hutchens et al.
patent: 6528320 (2003-03-01), Hutchens et al.
patent: 6579719 (2003-06-01), Hutchens et al.
patent: 6734022 (2004-05-01), Hutchens et al.
patent: 6811969 (2004-11-01), Hutchens et al.
patent: 6844165 (2005-01-01), Hutchens et al.
patent: 6881586 (2005-04-01), Hutchens et al.
patent: 6897072 (2005-05-01), Rich et al.
patent: 7071003 (2006-07-01), Hutchens et al.
patent: 7074619 (2006-07-01), Hutchens et al.
patent: 3321681 (1983-12-01), None
patent: 0084086 (1983-07-01), None
patent: 0333912 (1989-09-01), None
patent: 2235528 (1991-03-01), None
patent: 2235529 (1991-03-01), None
patent: 2236184 (1991-03-01), None
patent: 2236185 (1994-03-01), None
patent: WO 91/02961 (1991-03-01), None
patent: WO 92/13629 (1992-08-01), None
patent: WO 96/37777 (1996-11-01), None
patent: WO 96/40888 (1996-12-01), None
patent: WO 99/06833 (1999-02-01), None
Beavis, R. et al., “Expitaxial protein inclusion in sinapic acid crystals” J. Phys. D: Appl. Phys.26:442-447 (1993).
Brockman, A. et al., “Probe-immobilized affinity chromatography/mass spectrometry” Anal. Chem. 67(24):4581-5 (1995) [Abstract].
Brodbelt et al., “In Vivo Mass Spectrometric Determination of Organic Compounds in Blood with a Membrane Probe,” Anal. Chem., 59:454-458 (1987).
Carr et al., Analytical Biochemistry, vol. 157, pp. 396-406, 1986.
Cornish et al., “Laser Desorption Tandem Time-of-Flight Mass Spectrometry for Fragmentation Analysis of Biomolecules,” Abstract, Accession No. 4591121, Apr. 1993.
Dwyer, J. et al., “A novel sample preparation device for MALDI-MS” Intn'l Lab. 13A-13F (1997).
Fitzgerald, M. et al., “Direct characterization of solid phase resin-bound molecules by mass spectrometry” Bioorg. Med. Chem. Lett. 6(8):979-982 (1996) [Abstract].
Hillenkamp, F., “Laser desorption mass spectrometry: Mechanisms techniques and applications” Bordeaux Mass Spect. Conference Report 11A:354-362 (1988).
Hutchens, T. et al., FEBS, vol. 296, No. 1, pp. 99-102, 1992.
Hutchens, T. et al., “Differences in the confrontational state of a zinc-finger DNA-binding protein domain occupied by zinc and copper revealed by electrospray ionization mass spectrometry” Rapid Comm. in Mass Spect. 6:469-473 (1992).
Hutchens, T. et al., “New desorption strategies for the mass spectrometric analysis of marcromolecules” Rapid Comm. in Mass Spect. 7:576-580 (1993).
Jonsson, Gunnar P., et al., Plasma Desorption Mass Spectrometry of Peptides and Proteins Adsorbed on Nitrocellulose, Analytical Chemistry, 58:1084-1087 (1988).
Karas, M. et al., “Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons” Anal. Chem. 60:2299-2301 (1988).
Karas, M. et al., “Ultraviolet laser desorption of proteins up to 120,000 daltons” Bordeaux Mass Spect. Conference Report 11A:416-417 (1988).
Karas, M. et al., “UV laser desorption/ionization mass spectrometry of femtomol amounts of large proteins” Biomed. Environ. Mass Spectr. 18:841-843 (1989).
Mock, K. et al., “Sample Immobilization protocols for matrix-assisted laser desorption mass spectrometry” Rapid Comm. in Mass Spec. 6:233-238 (1994).
Nelson et al., “Mass spectrometric analysis of a trans-metal-binding peptide using matrix-assisted laser-desorption time-of-flight mass spectrometry. A demonstration of probe tip chemistry” Rapid Comm. Mass Spec. 6:4-8 (1992).
Nelson et al., “Mass spectrometric immunoassay” Anal. Chem. 67:1153-58 (1995), cited by other.
Rivera, A., “A summary statement: Probes for affinity mass spectrometry of phosphoproteins” Arp. 16, 1994.
Siuzdak, G. et al., “Applications of mass spectrometry in combinatorial chemistry” Biotech. Bioeng. 61(2):127-134 (1998) [Abstract].
Speir, J. et al., “Substrate-assisted laser desorption of neutral peptide molecules” Anal. Chem. 64:1041-1045 (1992).
Strupat, K. et al., “2,5-Dihydroxybenzoic acid: A new matrix for laser desorption-ionization mass spectrometry” Int'l J. Mass Spectr. and Ion Proc. 111:89-102 (1991).
Tang et al., Rapid Communication in Mass Spectrometry, vol. 6, pp. 365-368, 1992.
Tang et al., “Matrix-assisted laser desorption/ionization mass spectrometry of immobilized duplex DNA probes,”Nucleic Acids Research, 23(16):3126-3131 (1995).
Van Breemen et al., Time-Resolved Laser Desorption Mass Spectrometry. 1. Desorption of Performed Ions, Elsevier Scientific Publishing Company, International Journal of Mass Spectrometry and ion Physics 49 (1983): 36-51.
Xiang, F. et al., “A method to increase contaminant tolerance in protein matrix-assisted laser desorption/ionization by the fabrication of thin protein-doped polycrystalline films” Rapid Comm. in Mass Spec. 8:199-204 (1994).
Yip, T. et al., Protein Expression and Purification 2:355-362 (1991).
American Biotechnology Laboratory, Feb. 1994 cover, cover-p. 2 (1994).

Affiliated with

Also associated with

Rating

Probe and apparatus for desorption and ionization of analytes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Probe and apparatus for desorption and ionization of analytes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Probe and apparatus for desorption and ionization of analytes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4032503