Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2007-02-20
2009-08-18
Li, Ruixiang (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388100, C530S387300, C424S130100
Reexamination Certificate
active
07576185
ABSTRACT:
The present invention is directed to novel polypeptides having sequence similarity to GDNFR and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
REFERENCES:
patent: 2003/0204075 (2003-10-01), Wang
patent: WO99/50298 (1999-10-01), None
patent: WO02/068579 (2002-09-01), None
Airaksinen and Saarma, “The GDNF Family: Signalling, Biological Functions and Therapeutic Value”Nat. Rev. Neurosci. 3:383-394 (May 2002).
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Clark et al., Database GenBank Accession No. AY358198, Search Date: Apr. 9, 2004:Published: Oct. 3, 2003.
Clark et al., “The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment”Genome Research, XP001189293, Cold Spring Harbor Laboratory Press vol. 13:2265-2270 (2003).
Tracey, A. et al. Accession No. AL592426 (Creation Date: Jul. 5, 2001; Modification Date: May 18, 2005).
Zhou et al., “hgFRalpha-4: a new member of the GDNF receptor family and a candidate for NBIA”Pediatric Neurology25(2):156-161 (Aug. 2001).
Peer Bork and EUgene V. Koonin, Predicting functions from protein sequences—where are the bottlenecks? Nature Genetics, 18:313-318, 1998.
Grimaldi J. Christopher
Seshagiri Somasekar
Stinson Jeremy
Wood William I.
Zhang Zemin
Barnes Elizabeth M.
Dreger Ginger R.
Genentech Inc.
Goodwin & Procter LLP
Li Ruixiang
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