PRO20088 polypeptides

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C514S012200, C530S387300

Reexamination Certificate

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10196750

ABSTRACT:
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

REFERENCES:
patent: 5536637 (1996-07-01), Jacobs
Skolnick et al. (2000). From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends in Biotech. 18(1):34-39.
Bork, A. (2000). Powers and pitfalls in sequence analysis: the 70% hurdle. Genome Res. 10:398-400.
Doerks et al. (1998). Protein annotation: detective work for function prediction. Trends in Genetics. 146):248-250.
Smith et al. (1997). The challenges of genome sequence annotation or The devil is in the details. Nature Biotech. 15:1222-1223.
Brenner, S.E. (1999). Errors in genome function. Trends in Genetics. 15(4):132-133.
Bork et al. (1996). Go hunting in sequence databases but watch out for the traps. Trends in Genetics. 12(10):425-427.
Wells, J.A. (1990). Additivity of mutational effects in proteins. Biochemistry. 29(37):8509-8517.
Ngo et al. (1994). Computational complexity, protein structure prediction, and the Levinthal paradox. In Merz and Le Grand (Eds.) The Protein Folding Problem and Tertiary Structure Prediction. Birkhauser:Boston, pp. 492-495.
Pennica et al. (1998). WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc. Natl. Acad. Sci. USA. 95(25):14717-14722.
Haynes et al. (1998). Proteome analysis: biological assay or data archive. Electrophoresis 19:1862-1871.
Sen et al. (2000). Aneuploidy and cancer. Curr. Opin. Oncol. 12(1):82-88.
Hu et al. (2003). Analysis of genomic and proteomic data using advanced literature mining. Journal of Proteome Research. 2:405-412.
Chen et al. (2002). Discordant protein and mRNA expression in lung adenocarcinomas. Molecular and Cellular Proteomics. 1:304-313.
Saito-Hisaminato (2002). Genome-wide profiling of gene expression in 29 normal human tissues with a cDNA microarray. DNA Research. 9:35-45.
Qi et al. (2003). Identificaiton of genes responsible for osteoblast differentiation from human mesodermal progenitor cells. Proc. Natl. Acad. Sci. USA 100:3305-3310.
Lichtinghagen et al. (2002). Different mRNA and protein expression of matrix metalloproteinases 2 and 9 and tissue inhibitor of metalloproteanases 1 in benign and malignant prostate tissue. European Urology. 42:398-406.
Lian et al. (2001). Genomic and proteomic analysis of the myeloid differentiation program. Blood. 98:513-524.
Fessler et al. (2002). A genomic and proteomic analysis of activation of the human neutrophil by lipopolysaccharide and its mediation by p38 mitogen-activated protein kinase. The Journal of Biological Chemistry. 277(35):31291-31302.
Feroze-Merzoug et al. (2001). Molecular profiling in prostate cancer. Cancer and Metastasis Reviews. 20:165-171.
Gygi et al. (1999). Correlation between protein and mRNA abundance in yeast. Molecular and Cellular Biology. 19(3):1720-1730.
Madoz-Gurpide et al. (2003). Molecular analysis of cancer using DNA and protein microarrays. Adv. Exp. Med. Biol. 532:51-58.
Celis et al. (2000). Gene expression profiling: monitoring transcription and translation products using DNA microarrays and proteomics. FEBS Letters. 480:2-16.
Bustin et al. (2002). The value of microarray techniques for quantitative gene profiling in molecular diagnostics. TRENDS in Molecular Medicine. 8(6):269-272.
Valle et al. (2003). New approaches for biomarker discovery in lung cancer. Expert Rev. Mol. Diagn. 3(1):55-67.
Hittelman W.M. (2001). Genetic instability in epithelial tissues at risk for cancer. Ann. N Y Acad. Sci. 952:1-12.
Fleischhacker et al. (1995). DNA aneuploidy in morphologically normal colons from patients with colon cancer. Mod. Pathol. 8(4):360-365.
Hegde et al. (2000). A concise guide to cDNA microarray analysis. BioFeature. 29(3):548-562 (pp. 548, 550, 552-554, 556, 558-560, and 562 ONLY).
Quackenbush, J. (2002). Microarray data normalization and transformation. Nature Genetics Suppl. 32:496-501.
Lee et al. (2000). Importance of replication in microarray gene expression studies: statistical methods and evidence from repetitive cDNA hybridizations. Proc. Natl. Acad. Sci., USA. 97(18):9834-9839.
King, H.C. (2001). Gene expression profile analysis by DNA microarrays: promise and pitfalls. JAMA. 286(18):2280-2288.
Klein et al. Selection for Genes Encoding Secreted Proteins and Receptors.Proc. Natl. Acad. Sci., 93:7108-7113 (1996).
Ørntoft, T.F., et al., “Genome-Wide Study of Gene Copy Numbers, Transcripts, and Protein Levels in Pairs of Non-Invasive and Invasive Human Transitional Cell Carcinomas”, Molecular & Cellular Proteomics; 1.1:37-45 (2002).
Beer et al., “Gene-expression profiles predict survival of patients with lung adenocarcinoma”, Nature Biomedicine, vol. 98, No. 8, pp. 816-824, Aug. 2002.
Abe, N., et al., “An Increased High-Mobility Group A2 Expression Level is Associated with malignant Phenotype in Pancreatic Exocrine Tissue,”Br J Cancer—89(11):2104-9 (2003) Abstract.
Ando, M., et al., “Selective Apoptosis of Natural Killer-Cell Tumours by I-Asparaginase,”Br J Haematol.,—130(6):860-8 (2005) Abstract.
Aust, G., et al., “Human Thyroid Carcinoma Cell Lines and Normal Thyrocytes: Expression and Regulation of Matrix Metalloproteinase Inhibitor-1 Messenger-RNA and Protein,”Thyroid—7(5):713-24 (1997) Abstract.
Barnes, V.L., et al., “Expression of Embryonic Fibronectin Isoform EIIIA Parallels Alpha-Smooth Muscle Actin in Maturing and Diseased Kidney,”J Histochem Cytochem.—47(6):787-98 (1999) Abstract.
Bea, S., et al., “BMI-1 Gene Amplification and Overexpression in Hematological Malignancies Occur Mainly in Mantle Cell Lymphonas,”Cancer Res.—61(6):2409-12 (2001) Abstract.
Blaschke, V., et al., “Rapid Quantitation of Proinflammatory and Chemoattractant Cytokine Expression in Small Tissue Samples and Monocyte-Derived Dendritic Cells: Validation of a New Real-Time RT-PCR Technology,”J Immunol Methods.—246(1-2):79-90 (2000) Abstract.
Buckley, A.R., et al., “Butyrate-Induced Reversal of Dexamethasone Resistance in Autonomouse Rat Nb2 Lymphoma Cells,”Apoptosis.—2(6):518-28 (1997) Abstract.
Caberlotto, L. et al., “Alterations in Neuropeptide Y Levels and Y1 Binding Sites in the Flinders Sensitive Line Rats, A Genetic Animal Model of Depression,”Neurosci Lett.—265(3):191-4 (1999) Abstract.
Caberlotto, L., et al., “Neurokinin 1 Receptor and Relative Abundance of the Short and Long Isoforms in the Human Brain,”Eur J Neurosci.—17(9):1736-46 (2003) Abstract.
Choi, D., et al., “Characterization of Cyclin D2 Expression in Human Endometrium,”J Soc Gynecol Investig.—9(1):41-6 (2002) Abstract.
Couvelard, A., et al., “Human Chorionic Gonadotrophin Beta Expression In Malignant Barrett's Oesophagus,”Virchows Arch.—445(3):279-84 (2004) Abstract.
Dagenais, A., et al., “Downregulation of EnaC Activity and Expression by TNF-Alpha In Alveolar Epithelial Cells,”Am J. Physio Lung Cell Mol Physiol.—286(2):L301-11 (20040 Abstract.
De Boer, C.J., et al., “Involement of the CCNDI Gene in Hairy Cell Leukemia,”Ann Oncol.—7(3):251-6 (1996) Abstract.
Debieve, F., et al., “Inhibin and Activin Production and Subunit Expression in Human Placental Cells Cultured in Vitro,”Mol Hum Reprod.—6(8):743-9 (2000) Abstract.
Dong, Z., et al., “Expression of Membrane-Type Matrix Metalloproteinases 4, 5, and 6 in Mouse Corneas Infected with P. Aeruginosa,”I

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