Pro-micelle pharmaceutical compositions

Details Pro-micelle pharmaceutical compositions Pro-micelle pharmaceutical compositions

2005-10-04

2005-10-04

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

C424S455000, C424S456000, C424S498000, C530S303000, C530S306000, C530S383000, C530S399000, C514S002600, C514S003100

Reexamination Certificate

active

06951655

ABSTRACT:
The present invention provides pro-micelle compositions comprising a pharmaceutically active agent encapsulated with a membrane of esterified C12-C18fatty acids. In the mammalian intestine, exposure to C12-C18fatty acids results in conversion of the pro-micelle to a stable micelle that effectively delivers the pharmaceutically active agent to the systemic circulation. The present invention further provides methods of making and using such compositions.

REFERENCES:
patent: 4615885 (1986-10-01), Nakagame et al.
patent: 4837028 (1989-06-01), Allen
patent: 4849227 (1989-07-01), Cho
patent: 5552156 (1996-09-01), Burke
patent: 5656289 (1997-08-01), Cho et al.
patent: 5665700 (1997-09-01), Cho et al.
patent: 5858398 (1999-01-01), Cho

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