Pro drugs for selective drug delivery

Organic compounds -- part of the class 532-570 series – Organic compounds – Azo

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544232, 435 5, 435 6, 935 78, C07C24500, A01N 3326, C12Q 170

Patent

active

057735921

ABSTRACT:
A broad class of pharmaceutical agents which react directly with electron carriers or with reactive species produced by electron transport to release a pharmacologically active molecule to effect a therapeutic functional change in the organism by a receptor or nonrecepter mediated action.

REFERENCES:
patent: 2829148 (1958-04-01), Chalkley
patent: 2839542 (1958-06-01), Chalkley
patent: 2839543 (1958-06-01), Chalkley
patent: 2855303 (1958-10-01), Chalkley
patent: 2936235 (1960-05-01), Chalkley
patent: 3798131 (1974-03-01), Rounds et al.
patent: 4399131 (1983-08-01), Durckheimer
patent: 4599303 (1986-07-01), Yabusaki et al.
patent: 4626501 (1986-12-01), Landes
patent: 4656127 (1987-04-01), Mundy
patent: 4683194 (1987-07-01), Saiki et al.
patent: 4716106 (1987-12-01), Chiswell
patent: 5428163 (1995-06-01), Mills
Abuin, E., et al, Photochemistry and Photobiology, 30, 59-62 (1979).
Adam, W., et al, Photochemistry and Photobiology, 30, 45-48 (1979).
Adams, R., et al, "The Use of Oxalyl Chloride and Bromide for Producing Acid Chlorides, Acid Bromides or Acid Anhydrides", 599-611 (1920).
Agarwal, R.P., et al, Biochem. Pharmacol., 24, 693-701 (1975).
Agarwal, R.P., et al, Biochem. Pharmacol., 26, 359-367 (1977).
Allen, R.C., Chemical and Biological Generation of Excited States, 309-345 (1968).
Alston, T.A., et al, Biochemistry, 26, 4082-4085 (1987).
Ando, W., et al, Photochemistry and Photobiology, 30, 81-87 (1979).
Arakawa, H., et al, Chem. Pharm. Bull., 30(8), 3036-3039 (1982).
Asano, T., et al, Mol. Pharm., 13, 400-406 (1977).
Baker, B.R., "Design of Active-Site-Directed Irreversible Enzyme Inhibitors", 9 (1975).
Baker, B.R., et al, J. Med. Chem., 10, 682-685, 1101-1105, 1134-1138 (1967).
Baker, B.R., et al, J. Med. Chem., 11, 666-672 (1968).
Baldessarini, R.J., et al, Biochem. Pharmacology, 22, 247-256 (1973).
Baldwin, J.J., et al, J. Med. Chem., 18, 895-900 (1975).
Beard, N.A.., et al, Br. J. Pharmac., 54, 65-74 (1975).
Bechara, E.J.H., et al, Photochemistry and Photobiology, 30, 101-110 (1979).
Becker, Y., Pharmac. Ther., 10, 119-159 (1980).
Berger, A.W., et al, Photochemistry and Photobiology, 4, 1123-1127 (1965).
Bergstrand, H., et al, Molecular Pharmacology, 13, 38-43 (1977).
Berridge, M.J., Ann. Rev. Biochem., 56, 159-193 (1987).
Bertelli, A., et al, Experientia, 32, 361-362 (1976).
Bloxham, D.P., Biochem. J., 147, 531-539 (1975).
Bogan, D.J., et al, "Formation and Chemiluminescent Decomposition of Dioxetanes in the Gas Phase", 3-15 (1979).
Borchardt, R.T., et al, J. Medicinal Chem., 18(3), 300-303 (1975).
Bowen, E.J., et al, ed., "Luminescence in Chemistry", 183-190 (1968).
Brady, R.O., Biochim. Biophys. Acta, 70, 467-468 (1963).
Brasen, W.R., et al, Organic Syntheses, 585-589 (1952).
Bricker, L.A., et al, J. Biological Chem., 247(15), 4914-4915 (1972).
Brodbeck, U., ed., "Enzyme Inhibitors", 61-74, 223-244 (1980).
Bryan, L.E., et al, Antimicrob. Agents Chemother., 9(6), 928-938 (1976).
Burghuber, O.C., et al, Am. Rev. Respir. Dis., 131, 778-785 (1985).
Burr, J.G., "Chemi-and Bioluminescence", Marcel Dekker, Inc., N.Y., N.Y., 245-320 (1985).
Buu, N.T., et al, Br. J. Pharmac., 52, 401-406 (1974).
Carlin, S.C., et al, Mol. Pharm., 10, 194-203 (1974).
Catignani, G.L., et al, Life Sciences, 16, 1915-1922 (1975).
Chen, F.W.K., et al, Prostaglandins, 13, 115-125 (1977).
Chignard, M., et al, Prostaglandins, 14, 222-241 (1977).
Chiou, C.Y., et al, Br. J. Pharmac., 53, 279-285 (1975).
Coleman, J.E., J. Biol. Chem., 243(17), 4574-4587 (1968).
Collins, K.D., et al, J. Biol. Chem., 246(21), 6599-6605 (1971).
Collins, K.D., et al, J. Biol. Chem., 249(1), 136-142 (1974).
Counsell, R.E., et al, J. Medicinal Chem., 13(6), 1040-1042 (1970).
Coward, J.K., "Drug Action and Design: Mechanism-Based Enzyme Inhibitors", 13=27 (1979).
Cushman, D.W., et al, Biochimica et Biophysica Acta, 424, 449-459 (1976).
Dalton, C., et al, Prostaglandins, 7, 319-327 (1974).
D'Amato, R.F., et al, "Rapid Manual and Mechanized/Automated Methods for the Detection and Identification of Bacteria and Yeasts", 52-65 (1976).
Dawes, E.A., Microbial Energetics, 81-93 (1974).
DeClercq, E., et al, Life Sciences, 17, 187-194 (1975).
Deibel, Jr., M.R., et al, Biochemical Medicine, 25, 288-297 (1981).
Demain, A.L., Biochem. Soc. Symp., 48, 117-132 (1983).
Diliberto, Jr., E.J., et al, Biochemical Pharmacology, 22, 2961-1972 (1973).
D'Iorio, A., et al, Canadian J. of Biochemistry and Physiology, 41, 1779-1784 (1963).
Downing, D.T., et al, Biochem. Biophys. Research Comm., 40, 218-223 (1970).
Dreyer, J.F., "Self-Attenuating Ophthalmic Filter", Report WADD-TR-60-632, Feb. 1961, AD 322820.
Dreyer, J.F., et al, "Investigation of Materials and Systems for Protection Against Flash Blindness Effects of Nuclear Detonations," Report 68-38-CM, AD 688692 (1982).
Dreyer, J.F., Polacoat Inc., Tech. Report SEG-TR-65-50, 1-40, Oct. 1965.
Dreyer, J.F., Polacoat Inc., WADD Tech. Report 60-827, Contract AF 33(616)-6715, 1-20, Feb. 1961.
Dreyer, J.F., Reprint from J. Phys. and Colloid Chem., 52(5), 809-810 (1948).
Dreyer, J.F., unpublished paper presented at the Vth Intern'l Liquid Crystal Conf., in Stockholm, Sweden, Jun. 20, 1974.
Duggan, D.E., et al, J. Med. Chem., 18(9), 900-905 (1975).
Dulin, W.E., et al, Proc. Society for Exper. Biology and Medicine, 118, 499-501 (1965).
Dulin, W.E., et al, Proc. Society for Exper. Biology and Medicine, 121, 777-779 (1966).
Edwards, J.O., et al, "On the Formation and Reactivity of Dioxirane Intermediates in the Reaction of Peroxoanions with Organic Substrates", 63-70 (1979).
Ellenbogen, L., et al, Biochem. Pharm., 18, 683-685 (1969).
Ellenbogen, L., et al, Biochem. Pharm., 22, 939-947 (1973).
ElMasry, A.H., et al, J. Medicinal Chem., 18(1), 16-20 (1975).
Evans, D.P., et al, Br. J. Pharmac., 53, 409-418 (1975).
Ewatz, L., et al, Analytical Biochemistry, 71, 564-570 (1976).
Falcon, M.G., et al, J. Gen. Virol., 36, 199-202 (1977).
Fall, R.R., et al, J. Biol. Chem., 246(22), 6913-6928 (1971).
Ferone, R., J. Biol. Chem., 245(4), 850-854 (1970).
Ferraccioli, G., et al, J. Rheumatol., 11(3), 330-332 (1984).
Fimognari, G.M., et al, Biochemistry, 4, 2086-2090 (1965).
Forster, T., "Comparative Effects of Radiation", John Wiley & Sons, Inc., N.Y., N.Y., 300-325 (1980).
Free, C.A., et al, Biochem. Pharm., 20, 1421-1428 (1971).
Froesch, E.R., et al, Mol. Pharm., 3, 429-441 (1967).
Fuller, R.W., et al, Biochem. Pharmacology, 1981-1983 (1978).
Fuller, R.W., et al, J. Medicinal Chem., 18(3), 304-307 (1975).
Gale, G.R., et al, J. Med. Chem., 13(3), 571-574 (1970).
Gel'man, N.S., et al, Respiration and Phosphorylation of Bacteria, Plenum Press, N.Y., N.Y., 140-159 (1967).
Glamkowski, E.J., et al, J. Am. Chem. Soc., 10, 852-855 (1967).
Gorman, R.R., et al, Biochem. Biophys. Research Comm., 79(1), 305-313 (1977).
Gorsuch, J.D., "Studies of the Chemiluminescence of Luminol", MIT Ph.D. Thesis (1969).
Guldberg, H.C., et al, Pharmacological Reviews, 27(2), 135-206 (1975).
Hare, L.E., et al, J. Medicinal Chemistry, 17(1), 1-5 (1974).
Hartman, W.J., et al, J. Biol. Chem., 216, 507-529 (1955).
Hashiguchi, H., et al, Mol. Pharm., 13, 362-367 (1977).
Hashimoto, T., et al, Eur. J. Biochem., 24, 128-139 (1971).
Hidaka, H., Nature, 231, 54-55 (1971).
Hidaka, H., et al, Mol. Pharm., 9, 172-177 (1973).
Hidaka, H., et al, J. Pharm. Exp. Therp., 19(3), 384-392 (1974).
Hillcoat, B.L., et al, J. Biol. Chem., 242(20), 4777-4781 (1967).
Humphrey, S.M., et al, J. Surgical Research, 43, 187-195 (1987).
Huszti, Z., et al, J. Pharm. Exp. Therp., 192, 432-440 (1975).
Inagaki, M., et al, J. Biol. Chem., 260(5), 2922-2925 (1985).
Ito, Y., et al, "Thermal and Photosensitized Decomposition of Dimeric Valerophenone Peroxide Formed by Ozonation of Valerophenone Oxime Ether", 53-57 (1979).
Iverson, L.L., et al, J. Neurochemistry, 18, 1939-1950 (1971).
Iwai, H., J. Biochem., 76, 419-429 (1974).
Iwata, H., et al, Biochem. Pharmacology, 18, 955-957 (1969).
Iwata, H., et al, Biochem. Pharmacology, 22, 1845-1854 (1973).
Johns, D.G., et al, Biochem. Pharmacology, 19, 1528-1533 (1970).
Johnson, G.A., et al, J. Pharm. Exp. Therp., 168, 229-234 (1969).
Johnston, G.A.R.

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