Pro-drug forms of digoxin and method of preparing and using same

Details Pro-drug forms of digoxin and method of preparing and using same Pro-drug forms of digoxin and method of preparing and using same

1976-03-08

1977-05-03

Gotts, Lewis

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugate includes potentiator; or composition comprising...

536 7, A61K 31705

Patent

active

040215466

ABSTRACT:
There is provided, a novel pro-drug form of digoxin having the following formula: ##STR1## wherein R represents a member selected from the group consisting of a hydrogen atom, a residue of any naturally occurring amino acid, and a ##STR2## group, wherein X and Y, which may be the same or different, each represent a member selected from the group consisting of a methyl group and an ethyl group, or wherein X and Y may form a (CH.sub.2).sub.4 or (CH.sub.2).sub.5 heterocyclic ring with the N atom to which each of X and Y are attached, and a non-toxic inorganic or organic pharmaceutically acceptable acid addition salt thereof, with the proviso that:

REFERENCES:
patent: 3884905 (1975-05-01), Bodor

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