Prion test

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S040500, C530S300000, C530S350000, C424S130100, C424S139100, C424S184100

Reexamination Certificate

active

09913345

ABSTRACT:
The invention is related to diagnostic methods for detecting transmissible spongiform encephalopathies (TSEs) such as BSE and scrapie and related disease in humans. The invention provides use of guanidine thiocyanate (gdnSCN) or a functional equivalent thereof for treating at least one sample derived from a mammal, including humans for reducing the risk of scoring a false-positive test result in testing said sample for the presence of aberrant prion protein.

REFERENCES:
patent: 4806627 (1989-02-01), Wisniewski et al.
patent: 5565186 (1996-10-01), Prusiner et al.
patent: 6150172 (2000-11-01), Schmerr et al.
patent: WO 93 23432 (1993-11-01), None
patent: WO9710505 (1997-03-01), None
patent: WO97/37227 (1997-09-01), None
patent: WO9832334 (1998-07-01), None
patent: WO 99 19360 (1999-04-01), None
Bell, J.E., et al, “Prion protein immunocytochemistry—UK fife centre consensus report”, Neuropathology and Applied Neurobiology. 1997. 23(1):26-35.
Grathwohl, K.-U.D., et al, “Sensitive enzyme-linked immunosorbent assay for detection of PrP in crude tissue extracts from scrapie-affected mice.” Journal of Virological Methods, vol. 64, pp. 205-216, 1997.
Bell, J.E. et al, “Prion Protein Immunocytochemistry—UK Five Centre Consensus Report,” Neuropathology and Applied Neurobiology, 1997, 23, 26-35.
Oesch, Bruno et al., “Properties of the Scrapie Prion Protein: Quantitative Analysis of Protease Resistance,” Biochemistry, 1994, 33. 5926-5931.
Belt et al., Identification of the five allelic variants of the sheep PrP gene and their association with natural scrapie, Journal of General Virology, 1995, pp. 1-10.
Brown, Can Creutzfeldt-Jakob disease be transmitted by transfusion?1995, pp. 472-77, Rapid Science Publishers.
Diringer et al., Scrapie infectivity, fibrils and low molecular weight protein, Nature, Dec. 1983, 476-78, Macmillian Journals Ltd.
Doi et al., “Western Blot Detection of Scrapie-associated Fibril Protein in Tissues outside the Central Nervous System from Preclinical Scrapie-infected Mice,”J. gen. Virol, 69, pp. 955-960, 1988.
Fraser et al., Transmission of bovine spongiform encephalopathy to mice, Journal of Small Animal Practice, 1988, p. 565, vol. 29.
Fraser, Murine Scrapie Strains, BSE Models and Genetics, Sub-acute Spongiform Encephalopathies, pp. 131-36, the Netherlands.
Fraser et al., Studies of the Lymphoreticular System in the Pathogenesis of Scrapie: The Role of Spleen and Thymus, J. Comp. Path., 1978, pp. 563-73, vol. 88.
Hadlow et al., Natural Infection of Suffolk Sheep with Scrapie Virus, The Journal of Infectious Diseases, Nov. 1982, pp. 657-64.
Hadlow et al., “Virologic and Neurohistologic Findings in Dairy Goats Affected with Natural Scrapie,”Vet. Pathol. 17, pp. 187-199, 1980.
Hilmert et al., A rapid and efficient method to enrich SAF-protein from scrapie brains of hamsters, Bioscience Reports, 1984, pp. 165-70, vol. 4.
Ikegami et al. “Pre-clinical and clinical diagnosis of scrapie by detectiion of PrP protein in tissues of sheep,”The Veterinary Record, pp. 271-75, Mar. 23, 1991.
Korth et al., “Prion (PrPSc)-specific epitope defined by a monoclonal antibody,”Nature, vol. 390, pp. 74-75.
Meiner et al., Presence of prion protein in peripheral tissues of Libyan Jews with Creutzfeldt-Jakob disease, Neurology, Jul. 1992, pp. 1355-60, vol. 42.
Mohri et al., Immunodetection of a disease specific PfP fraction in scapie-affected sheep and BSE-affected cattle, Veterinary Record, 1992, pp. 537-39, vol. 131.
Muramatsu et al. “Detection of PrPscin sheep at the preclinical stage of scrapie and its significance for diagnosis of insidious infection,”Arch Virol, 134, pp. 427-32, 1993.
Muramoto et al., Accumulation of Abnormal Prion Protein in Mice Infected with Creutzfeldt-Jakob Disease via Intraperitoneal Route: A Sequential Study, American Journal of Pathology, Nov. 1993, pp. 1470-79, vol. 143, No. 5.
O'Rourke et al. “Monoclonal Antibody F89 160.1.5 Defines a Conserved Epitope on the Ruminant Prion Protein,”Journal of Clinical Microbiology, vol. 36, No. 6, pp. 1750-55, Jun. 1998.
O'Rourke et al. “Preclinical detection of PrPscin nictitating membrane lymphoid tissue of sheep,”The Veterinary Record, pp. 489-91, May 2, 1998.
Schreuder, Animal Spongiform Encephalopathies—An Update, Part I. Scrapie and Lesser Known Animal Spongiform Encephalopathies, Veterinary Quarterly, Oct. 1994, pp. 174-81, vol. 16, No. 3.
Schreuder, Animal Spongiform Encephalopathies—An Update, Part II. Bovine Spongiform Encephalopathy (BSE), Veterinary Quarterly, Oct. 1994, pp. 182-92, vol. 16, No. 3.
Schreuder et al., “Tonsillar biopsy and PrPscdetection in the pre-clinical diagnosis of scrapie,”Papers and Articles, pp. 1-9, Apr. 15, 1998.
Shinagawa et al. “Immunoreactivity of a Synthetic Pentadecapeptide Corresponding to the N-Terminal Region of the Scrapie Prion Protein,”J. gen. Virol. 67, pp. 1745-50, 1986.
Van Keulen et al., Immunohistochemical Detection and Localization of Prion Protein in Brain Tissue of Sheep with Natural Scapie, Vet Pathol, 1995, pp. 299-308, vol. 32.

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