Prion protein standard and method of making the same

Details Prion protein standard and method of making the same Prion protein standard and method of making the same

2005-11-08

2005-11-08

Falk, Anne-Marie (Department: 1632)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S001100, C800S004000, C800S013000, C800S018000

Reexamination Certificate

active

06962975

ABSTRACT:
The invention provides prion protein standards for use as reference materials for prion detection. The standard may be species specific, i.e. the standard is comprised of a preparation for detection of a single strain prion or it may be prepared to allow detection of multiple prion strains simultaneously. The invention also provides methods of preparing the prion protein standards using a group of non-human host mammals which have their genome manipulated with respect to genetic material related to a PrP gene such that the mammals are susceptible to infection with a prion which generally only infects an animal which is genetically diverse from the host.

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