Prion protein standard and method of making same

Details Prion protein standard and method of making same Prion protein standard and method of making same

1998-11-25

2000-02-01

Campell, Bruce R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

800 4, 800 13, 530350, C07K 1400, C12N 1500

Patent

active

060205377

ABSTRACT:
The invention provides prion protein standards for use as reference materials for prion detection. The standard may be species specific, i.e. the standard is comprised of a preparation for detection of a single strain prion or it may be prepared to allow detection of multiple prion strains simultaneously. The invention also provides methods of preparing the prion protein standards using a group of non-human host mammals which have their genome manipulated with respect to genetic material related to a PrP gene such that the mammals are susceptible to infection with a prion which generally only infects an animal which is genetically diverse from the host.

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