Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Scleroproteins – e.g. – fibroin – elastin – silk – etc.
Patent
1995-05-01
1998-05-26
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Scleroproteins, e.g., fibroin, elastin, silk, etc.
530402, 530410, 514 8, 514 21, 514801, 435236, 435238, A61K 3817, C12N 706
Patent
active
057566780
ABSTRACT:
It has been discovered that it is possible to treat solutions of connective tissue material for the inactivation of prions in a manner such that connective tissue molecules are not adversely affected by the inactivation treatment. For example, solubilized atelopeptide collagen can be treated with sodium hydroxide for the inactivation of prions and other infectious agents without affecting the ability of the solubilized collagen to form stable fibers. In accordance with the present invention, a first method for the treatment of connective tissue materials such as collagen for the inactivation of prions and other infective agents, to obtain at least 5 logs of protection, comprises the following steps:
REFERENCES:
patent: 3131130 (1964-04-01), Oneson
patent: 3530037 (1970-09-01), Nishihara
patent: 4511653 (1985-04-01), Play et al.
patent: 5616689 (1997-04-01), Shenoy et al.
Steinbach, Arzneim-Forsch/Drug Res., No. 42 (I), Nr. 1, pp. 85-89, 1992.
Brown et al, The J. of Infectious Diseases, vol. 153, No. 6, pp. 1145-1148, 1986.
Taylor et al, Arch. Virol., vol. 139, pp. 313-326, 1994.
P. Brown et al., "Newer Data on the Inactivation of Scrapie Virus or Creutzfedt-Jakob Disease Virus in Brain Tissue", The J. of Infectious Diseases, vol. 153, No. 6, pp. 1145-1148 (1986).
Wallace et al., "Multiple Denaturational Transitions in Fibrillar Collagen", Biopolymers, vol. 25, pp. 1875-1893 (1986).
Dr. Steinbach, "Recommendations for Minimizing the Risk of Infection by Agents Causing Zoonoses and Other Animal Infections in Manufacture of Medicinal Products", Arzneim-Forsch/Drug Res., No. 42 (I), Nr. 1, pp. 85-89 (1992).
"Public Health Issues Related to Animal and Human Spongiform Encephalopathies: Memorandum from A WHO Meeting", Bulletin of the World Health Organization, No. 70 (2), pp. 183-190 (1992).
D.R. Ernest et al., "Comparative Analysis of Scrapie Agent Inactivation Methods", J. Vicological Methods, 41:193-202 (1993).
S.B. Prusiner, "Biology and Genetics of Prion Diseases", Annu. Rev. Microbiol., 48:655-686 (1994).
D. M. Taylor et al., "Decontamination Studies with the Agents of Bovine Spongiform Encephalopathy and Scrapie", Arch. Virol., 139:313-326 (1994).
Revak Timothy T.
Shenoy Vivek N.
Cohesion Technologies, Inc.
Mohamed Abdel A.
Tsang Cecilia J.
LandOfFree
Prion inactivation in connective tissue materials does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Prion inactivation in connective tissue materials, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prion inactivation in connective tissue materials will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1961752