Prion diagnostic test

Details Prion diagnostic test Prion diagnostic test

2006-01-31

2006-01-31

Olsen, Kaj K. (Department: 1753)

Chemistry: electrical and wave energy

Processes and products

Electrophoresis or electro-osmosis processes and electrolyte...

C204S450000, C204S518000, C435S007920

Reexamination Certificate

active

06991715

ABSTRACT:
The claims provide for detecting prions in a sample by (a) subjecting a sample to membrane-based electrophoresis to separate and/or concentrate at least some prions present in the sample; and (b) detecting and or identifying the presence of the separated and/or concentrated prions.

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patent: WO 01/78878 (2001-10-01), None
Prusiner, S.B., “Prions”, Proc. National Acad. Sci., Nov. 10, 1998 Abstract only.
Fischer, M.B. et al., “Binding of disease-associated prion protein to plasminogen”, Nature, Nov. 23, 2000, pp. 479-483 Abstract only.
Brown P. et al., “Blood infectivity and the prospects for a diagnostic screening test in Creutzfeldt-Jakob disease”, J. Lab Clin Med, Apr. 2001 Bibliography only.
Yokoyama, T. et al., “In Vivo Conversion of Cellular Prion Protein to Pathogenic Isoforms, as Monitored by Conformation-specific Antibodies”, J. Biol. Chem., vol. 276, Issue 14, pages Abstract only.
MacGregor I., “Prion protein and developments in its detection”, Transfus Med., Feb. 2001 Abstract only.
MacGregor I. et al., “Distribution of normal prion protein in blood”, Elsevier Scient, Feb. 2000 Bibliography only.
MacGregor I. et al., “Application of a time-resolved fluoroimmunoassay for the analysis of normal prion protein in human blood and its components”, Karger, Vox Sang 1999, Abstract only.
Horvath, Stephen Z. et al., “Multifunctional Apparatus for Electrokinetic Processing of Proteins”, Electrophoresis 1994, vol. 15, pp. 968-971.

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