Primers targeted to CYP2D6 gene for detecting poor metabolizers

Details Primers targeted to CYP2D6 gene for detecting poor metabolizers Primers targeted to CYP2D6 gene for detecting poor metabolizers

1994-03-02

1997-07-15

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 911, 435 912, 536 231, 536 235, 536 243, 536 2431, 935 76, 935 77, 935 78, C07H 2104, C12P 1934, C12Q 168

Patent

active

056484828

ABSTRACT:
A method for the detection of poor metabolizers of drugs using PCR technology is described comprising a) optionally amplifying a gene coding for an enzyme known to be responsible for the metabolization of drugs, thereby separating it from possible closely related pseudogens,
b) amplifying different allelic forms of the gene of step a) and c) detecting the product of step b). Primers for amplification of the genes responsible for the debrisoquine or acetylation phenotype are also disclosed.

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