Primers for exons of variants of RHCE and RHD genes

Details Primers for exons of variants of RHCE and RHD genes Primers for exons of variants of RHCE and RHD genes

2008-09-09

2009-11-03

Martinell, James (Department: 1634)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

Reexamination Certificate

active

07612193

ABSTRACT:
Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.

REFERENCES:
patent: 7449295 (2008-11-01), Hashmi et al.

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