Primers and methods for detecting mutations in the procollagen I

Details Primers and methods for detecting mutations in the procollagen I Primers and methods for detecting mutations in the procollagen I

1992-11-13

1996-09-24

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 2431, 536 2433, C12Q 168, C07H 2104, C12P 1934

Patent

active

055589880

ABSTRACT:
The invention provides probes and primers for amplifying certain regions of genes for structural proteins of cartilage and methods for detecting mutations in these genes isolated from the nucleic acid of cells suspected of exhibiting mutant structural protein gene expression or having mutant structural protein genes. The invention also provides methods for determining a genetic predisposition for a disease that alters the structure or function of cartilage because of a mutation in a gene for a structural protein of cartilage in a mammal.

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