Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-11-14
2006-11-14
Sisson, Bradley L. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S183000, C435S287200, C536S023100, C536S024300, C536S024330
Reexamination Certificate
active
07135284
ABSTRACT:
The present invention provides novel nucleic acid labeling techniques that generate nucleic acid probes with specific activities at least ten fold higher than the levels obtained using standard labeling methods. Specifically, the methods of the invention provides methods of producing nucleic acid probes that each comprises multiple labeled nucleotides. The methods can be used to generate RNA, DNA or hybrid probes. The invention also provides reaction mixtures and kits for the practice of the methods of the invention and compositions comprising the probes generated according to the methods of the invention.
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Behlke Mark Aaron
Devor Eric Jeffrey
James Shale Anthony
Walder Joseph Alan
Integrated DNA Technologies, Inc.
Michael & Best & Friedrich LLP
Sisson Bradley L.
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