Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-08-28
2011-10-11
Woolwine, Samuel (Department: 1637)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S024330, C435S006120, C435S091200
Reexamination Certificate
active
08034917
ABSTRACT:
An oligonucleotide composition is provided. The subject composition comprises: a mixture of at least 10 of sets of oligonucleotides, wherein each of the sets of oligonucleotides comprises at least 100 different oligonucleotides of the following formula: X1—V—X2, wherein: X1and X2provide binding sites for a pair of PCR primers and V is a variable region that has a variable nucleotide sequence that is complementary to one or more discrete regions of a mammalian genome; the nucleotide sequences of X1and X2are the same for each oligonucleotide of a set and different for oligonucleotides of different sets; and the variable regions of each set are complementary to different discrete regions of said mammalian genome. Methods of using the composition and kits containing the composition are also provided.
REFERENCES:
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Muller, S., et al. Toward a multicolor chromosome bar code for the entire human karyotype by fluorescence in situ hybridization. Human Genetics. 1997, vol. 100, pp. 271-278.
Ried, T., et al. Chromosome painting: a useful art. Human Molecular Genetics. 1998, vol. 7, No. 10, pp. 1619-1626.
Une, T., et al. Assessment of molecular cytogenetic methods for the detection of chromosomal abnormalities. Acta Medica Okayama. 2006, vol. 60, No. 5, pp. 279-287.
Wu, H., et al. Delineation of an isodicentric Y chromosome in a mosaic 45,X/46,X,idic(Y)(qter-p11.3::p11.3-qter) fetus by SRY sequencing, G-banding, FISH, SKY and study of distribution in different tissues. Journal of the Formosan Medical Association. 2007, vol. 106, No. 5, pp. 403-410.
Agilent Technologie,s Inc.
Bozicevic, Field & Francis
Field Bret E.
Keddie James S.
Woolwine Samuel
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