Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2007-08-21
2007-08-21
Hayes, Robert C. (Department: 1649)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
10977113
ABSTRACT:
The invention provides an isolated squirrel monkey prokineticin receptor 2 (PKR2) polypeptide containing the amino acid sequence referenced as SEQ ID NO:2. The invention also provides an isolated chimpanzee PKR2 containing the amino acid sequence referenced as SEQ ID NO:4. Also provided are methods of identifying PKR2 agonists and antagonists using the squirrel monkey PKR2 polypeptide. Additionally, the invention provides an isolated rhesus monkey PK2 polypeptide containing the amino acid sequence referenced as SEQ ID NO:6. Nucleic acid molecules encoding the disclosed polypeptides further are provided by the invention.
REFERENCES:
patent: 5891720 (1999-04-01), Moore et al.
patent: 2004/0235732 (2004-11-01), Zhou et al.
patent: 2006/0019338 (2006-01-01), Zhou
Li 2001. Molecular Pharmacology 59:692-698.
Lin 2002. Journal of Biological Chemistry 277:19276-19280.
Gehlert et al., “Cloning and Characterization of Rhesus Monkey Neuropeptide Y Receptor Subtypes”Peptides, 22:343-350, Elsevier Science Inc. (2001).
Masuda et al., “Isolation and Identification of EG-VEGF/Prokineticins as Cognate Ligands for Two Orphan G-Protein-Coupled Receptors,”Biochemical and Biophysical Research Communications, 293:396-402, Elsevier Science (USA) (2002).
DLA Piper (US) LLP
Hayes Robert C.
Kolker Daniel E.
The Regents of the University of California
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