Primate lentivirus antigenic compositions

Details Primate lentivirus antigenic compositions Primate lentivirus antigenic compositions

1994-01-27

1998-12-22

Smith, Lynette F.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

4241991, 4242081, 530350, 530395, C12N 700, C12N 701, C07K 100, A61K 3912

Patent

active

058518134

ABSTRACT:
Molecular clones of primate lentiviruses that harbor an engineered non-revertible null mutation in the nef gene and which may further include a non-revertible null mutation in one or more non-essential genetic elements, vif, vpr, vpx, vpu, Negative Regulatory Element, nuclear factor .kappa.B-binding element, or Sp1 binding element sequences are disclosed. Intact viruses containing such mutant genomes are also disclosed. These infectious, nonpathogenic viruses are capable of eliciting a protective host immune response and, thus, are useful as a vaccine that protects against AIDS in human subjects.

REFERENCES:
Kestler III et al., Cell, vol. 65, pp. 651-662, May 17, 1991.
Desrosiers, Annual Rev. Immunol., vol. 8, pp. 557-578, (1990).
Putney et al., AIDS Vaccine Research and Clinical Trials, pp. 361-367 (1990).
Zagury et al., AIDS Research and Human Retroviruses, vol. 6, No. 9, pp. 1079-1085, Sep. 1990.
Regier et al., AIDS Research and Human Retroviruses, vol. 6, No. 11, pp. 1221-1231, (1990).
Hattori et al., Proc. Natl. Acad. Sci. USA, vol. 87, pp. 8080-8084, Oct. 1990.
Palca, Science, vol. 248, p. 1078.
Cohen et al., Journal of Virology, vol. 64, No. 6, pp. 3097-3099, Jun. 1990.
Kestler et al., Science, vol. 248, pp. 1109-1112, Jun. 1990.
Lu et al., Journal of Virology, vol. 64, No. 10, pp. 5226-5229, Oct. 1990.
Desrosiers, Nature, vol. 345, pp. 288-289, May 24, 1990.
Huet et al., Nature, vol. 345, pp. 356-359, May 24, 1990.
Koff et al., AIDS, vol. 3 (suppl 1), pp. s125-s129, (1989).
Hu et al., Virology, vol. 173, pp. 624-630, Dec. 1989.
Trono et al., Cell, vol. 59, pp. 113-120, Oct. 6, 1989.
Lu et al., Journal of Virology, vol. 63, No. 9, pp. 4115-4119, Sep. 1989.
Desrosiers et al., Proc. Nat. Acad. Sci. USA, vol. 86, pp. 6353-6357, Aug. 1989.
Cullen et al., Cell, vol. 58, pp. 423-426, Aug. 11, 1989.
Terwilliger et al., Proc. Natl. Acad. Sci. USA, vol. 86, pp. 5163-5167, (1989).
Green et al., Cell, vol. 58, pp. 215-223, Jul. 14, 1989.
"The Scientific and Social Challenge", AIDS, Montreal, Quebec, Canada, p. 219, Jun. 1989.
Guyader et al., The EMBO Journal, vol. 8, No. 4, pp. 1169-1175, Apr. 1989.
Fauci et al., Annals of Internal Medicine, vol. 110, No. 5, pp. 373-385, Mar. 1, 1989.
Niederman et al., Proc. Natl. Acad. Sci. USA, vol. 86, pp. 1128-1132, Feb. 1989.
Malim et al., Cell, vol. 58, pp. 205-214, Jul. 14, 1989.
Desrosiers, Annual Review of Microbiology, vol. 42, pp. 607-625, (1988).
Naidu et al., Journal of Virology, vol. 62, No. 12, pp. 4691-4696, Dec. 1988.
Matthews et al., Scientific American, pp. 120-127, Oct. 1988.
Baltimore, Nature, vol. 335, pp. 395-396, Sep. 29, 1988.
Ahmad et al., Science, vol. 241, pp. 1481-1485, Sep. 16, 1988.
Zagury et al., Nature, vol. 332, pp. 728-731, Apr. 21, 1988.
Fauci, Science, vol. 329, pp. 617-622, Feb. 5, 1988.
Guy et al., Nature, vol. 330, pp. 266-269, Nov. 19, 1987.
Chakrabarti et al., Nature, vol. 328, pp. 543-547, Aug. 6, 1987.
Franchini et al., Nature, vol. 328, pp. 539-543, Aug. 6, 1987.
Hirsch et al., Cell, vol. 49, pp. 307-319, May 8, 1987.
Clavel et al., The New England Journal of Medicine, vol. 316, No. 19, pp. 1180-1185, May 7, 1987.
Luciw et al., Proc. Natl. Acad. Sci, USA, vol. 84, pp. 1434-1438, Mar. 1987.
Franchini et al., Virology, vol. 155, pp. 593-599 (1986).
Terwilliger et al., Journal of Virology, vol. 60, No. 2, pp. 754-760, Nov. 1986.
Quinn et al., Science, vol. 234, pp. 955-963, Nov. 21, 1986.
Fisher, Science, vol. 233, pp. 655-659, Aug. 8, 1986.
Macdonald, Public Health Reports, vol. 101, No. 4, pp. 341-348, Jul.-Aug. 1986.
Curran, Science, vol. 229, pp. 1352-1357, Sep. 27, 1985.
Crowl et al., Cell, vol. 41, pp. 979-986, Jul. 1985.
Daniel et al., Science, vol. 228, pp. 1201-1204, Jun. 7, 1985.
Allan et al., Science, vol. 228, pp. 1091-1093, May 31, 1985.
Barin et al., Science, vol. 228, pp. 1094-1096, May 31, 1985.
Robey et al., Science, vol. 228, pp. 593-595, May 3, 1985.
Muesing et al., Nature, vol. 313, pp. 450-458, Feb. 7, 1985.
Ratner et al., Nature, vol. 313, pp. 277-284, Jan. 24, 1985.
Wain-Hobson et al., Cell, vol. 40, pp. 9-17, Jan. 1985.
Shaw et al., Science, vol. 226, pp. 1165-1171, Dec. 7, 1984.
Hahn et al., Nature, vol. 312, pp. 166-169, Nov. 8, 1984.
Sarngadharan et al., Science, vol. 224, No. 4648, pp. 506-508, May 4, 1984.
Schupbach et al., Science, vol. 224, pp. 503-505, May 4, 1984.
Gallo et al, Science, vol. 224, pp. 500-503, May 4, 1984.
Essex et al., Science, vol. 220, pp. 859-862, May 20, 1983.
Chermann et al., Science, vol. 220, pp. 868-871, May 20, 1983.
Haynes, 1993, "Scientific and Social Issues of Human . . ." Science 260: 1279-1286.
Fast, et al., 1994, "Efficacy trials of AIDS vaccines: how science . . ." Current Biology 691-697.
Brown, 1993, "AIDS vaccine trials viewed . . . " The Washington Post Newspaper, Jun. 10, 1993.
Greene, 1993, "AIDS and the immune system . . ." Scientific American, Sep. 1993, pp. 99-105.
Shibata et al., 1990, "Mutational analysis of . . ." J. Virol. 64(2): 742-747.

Affiliated with

Also associated with

Rating

Primate lentivirus antigenic compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Primate lentivirus antigenic compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Primate lentivirus antigenic compositions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2046121