Primary structure for functional expression from complementary D

Details Primary structure for functional expression from complementary D Primary structure for functional expression from complementary D

1992-07-29

1994-10-18

Low, Christopher S. F.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 4351723, 4353201, 4352523, 4352402, 935 11, 935 24, 935 56, 536 235, C12N 1512, C12N 1510, C12N 1563

Patent

active

053567757

ABSTRACT:
This invention is directed to the cloning of the gene which encodes an ATP-sensitive K.sup.+ channel in rat outer medulla cells, isolated cDNA sequences which encode said ATP-sensitive K.sup.+ channels, isolated proteins produced by said cDNA sequences, and agents capable of binding to said proteins. Further included in the invention are methods for identifying other members of the family of ATP-sensitive potassium channels (the ROMK1 family of channel proteins), identifying, isolating, and cloning the genes which encode ROMK1 associated polypeptides, identifying agents capable of binding to other members of the family, modulating expression of said family of ATP-sensitive potassium channels, and modulating the activity of said family of ATP-sensitive potassium channels. Additionally, included in the invention are methods for identifying drugs which function as K.sub.ATP channel openers and K.sub.ATP channel closers.

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