Primary rat hepatocyte toxicity modeling

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical

Reexamination Certificate

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C435S006120, C700S030000, C702S022000, C707S793000

Reexamination Certificate

active

07469185

ABSTRACT:
The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

REFERENCES:
patent: 5811231 (1998-09-01), Farr et al.
patent: 6160105 (2000-12-01), Cunningham et al.
patent: 6203987 (2001-03-01), Friend et al.
patent: 6218122 (2001-04-01), Friend et al.
patent: 6228589 (2001-05-01), Brenner
patent: 6365352 (2002-04-01), Yerramilli et al.
patent: 6372431 (2002-04-01), Cunningham et al.
patent: 6403778 (2002-06-01), Cunningham et al.
patent: WO 94/17208 (1994-08-01), None
patent: WO 97/13877 (1997-04-01), None
patent: WO 97/16732 (1997-05-01), None
patent: WO 99/12118 (1999-03-01), None
patent: WO 99/27090 (1999-06-01), None
patent: WO 00/12760 (2000-03-01), None
patent: WO 00/28092 (2000-05-01), None
patent: WO 00/39336 (2000-07-01), None
patent: WO 00/47761 (2000-08-01), None
patent: WO 00/63435 (2000-10-01), None
patent: WO 01/02609 (2001-01-01), None
patent: WO 01/11076 (2001-02-01), None
patent: WO 01/14425 (2001-03-01), None
patent: WO 01/20043 (2001-03-01), None
patent: WO 01/23886 (2001-04-01), None
patent: WO 01/25473 (2001-04-01), None
patent: WO 01/32928 (2001-05-01), None
patent: WO 01/36684 (2001-05-01), None
patent: WO 01/38579 (2001-05-01), None
patent: WO 01/44512 (2001-06-01), None
patent: WO 01/63279 (2001-08-01), None
patent: WO 02/31704 (2002-04-01), None
patent: WO 03/085083 (2003-10-01), None
patent: WO 03/095624 (2003-11-01), None
patent: WO 03/100030 (2003-12-01), None
Peng, JBC, 271(6):3324-3327 (1996).
GenBank Acc. No. AA799479 (Apr. 30, 1998).
GenBank Acc. No. AI177366 (Jan. 20, 1999).
GenBank Acc. No. M25823 (Apr. 27, 2993).
GenBank Acc. No. AA891812 (Jan. 25, 1999).
Adamson & Harman et al.,Biochem. Pharmacol., 45: 2289-2294 (1993).
Butterworth et al.,Cancer Res., 49: 1075-1084 (1989).
Cai et al.,J. Med. Chem., 41: 1970-1979 (1998).
Calabrese et al.,J. Amer. College Toxicol., 15: 62-69 (1996).
Castell et al.,Cell Biol. Toxicol., 13: 331-338 (1997).
Chan et al.,Proc. Natl. Acad. Sci. U.S.A.., 98: 4611-4616 (2001).
Chanda et al.,Hepatology, 21: 477-486 (1995).
Chen et al.,J. Biol. Chem.., 275: 22619-22622 (2000).
Chisholm et al.,Am. J. Physiol., 276: G1165-G1173 (1999).
Chou et al,Proc. Natl. Acad. Sci. U.S.A., 98: 8113-8118 (2001).
Christian et al.,Toxicol. Appl. Pharmacol., 82: 239-255 (1986).
Clive et al.,Fundam. Appl. Toxicol., 3: 587-602 (1983).
Coles et al.,Arch. Biochem. Biophys., 264: 253-260 (1988).
Conforti et al.,Agents Actions, 40: 176-180 (1993).
Coni et al.,Hepatology, 17: 1109-1116 (1993).
Corell et al.,Acta Pharmacol. Toxicol. (Copenh), 45:232-239 (1979).
Corton & Stauber,Toxicol. Sci., 58: 217-219 (2000).
Corton et al.,Cancer Lett., 134: 61-71 (1998).
Corton et al.,Cancer Lett., 137: 9-15 (1999).
Corton et al.,Mol. Pharmacol., 54: 463-473 (1998).
Crosby et al.,Toxicol. Appl. Pharmacol., 169: 205-221 (2000).
Cunningham et al.,Ann. N.Y. Acad. Sci., 919: 52-67 (2000).
D'Mello et al.,Exp. Toxicol. Pathol., 51: 549-553 (1999).
Davis et al.,Cancer Res., 60: 2887-2891 (2000).
De Fabiani et al.,J. Biol. Chem., 276: 30708-30716 (2001).
Del Giudice et al.,IL Farmaco., 51: 693-698 (1996).
Delaney & Timbrell,Xenobiotica., 25: 1399-1410 (1995).
Diel et al.,J. Steroid Biochem. Mol. Biol., 73: 1-10 (2000).
Dodds & Rivory,Mol. Pharmacol., 56: 1346-1353 (1999).
Dos Santos et al.,J. Am. Soc. Nephrol., 8: 361-367 (1997).
Duivenvoorden et al.,Biochem. Biophys. Res. Commun., 215: 598-605 (1995).
Dutar et al.,Brain Res., 527: 32-40 (1990).
Eadie et al.,Med. Toxicol. Adverse Drug Exp., 3: 85-106 (1988).
Eldridge et al.,Carcinogenesis, 11: 2245-2251 (1990).
Ellis & Isaacs,Cancer Res., 45: 6041-6050 (1985).
Emmison et al.,Biochim. Biophys. Acta, 1083: 147-152 (1991).
Enomoto et al.,Toxicol. Sci., 59: 169-177 (2001).
Falzon et al.,Br. J. Exp. Pathol., 66: 527-534 (1985).
Fan & Rozman,Toxicol. Lett., 75: 209-216 (1995).
Fan et al.,J. Biol. Chem.., 271: 24698-24710 (1996).
Farag & Hassib,Clin. Sci.(Lond), 84: 387-390 (1993).
Farr & Dunn,Toxicol. Sci., 50: 1-9 (1999).
Fernandez-Tome & Sterin-Speziale,Pharmacology, 48: 341-348 (1994).
Ficazzola et al.,Carcinogenesis, 22: 1271-1279 (2001).
Fielden & Zacharewski,Toxicol. Sci., 60: 6-10 (2001).
Fitten et al.,J. Gerontol., 42: 681-685 (1987).
Fracasso et al.,Agents Actions, 22: 3-4 (1987).
Fracasso et al.,Agents Actions, 31: 313-316 (1990).
Froesch et al.,J. Biol. Chem., 274: 6469-6475 (1999).
Frueh et al.,Mol. Pharmacol., 51: 363-399 (1997).
Fulgencio et al.,Biochem. Pharmacol., 62: 439-446 (2001).
Furr,Ann. N.Y. Acad. Sci., 761: 79-96 (1995).
Furr,Eur. Urol., 29: 83-95 (1996).
Ganem & Jefcoate,Toxicol. Appl. Pharmacol., 150: 68-75 (1998).
Garcia-Allan et al.,J. Biochem. Mol. Toxicol.., 14: 65-72 (2000).
Gerhold et al.,Physiol. Genomics., 5: 161-170 (2001).
Ghatineh et al.,Arch. Toxicol., 66: 660-668 (1992).
Goll et al.,Toxicol. Appl. Pharmacol., 160: 21-32 (1999).
Gram & Bentsen,Acta Neurol. Scand. Suppl., 97: 81-90 (1983).
Greaves et al.,Cancer Res., 53: 3919-3924 (1993).
Green et al.,Toxicol. Appl. Pharmacol., 76: 139-149 (1984).
Guardavaccaro et al.,Mol. Cell. Biol., 20: 1797-17815 (2000).
Hamada et al.,Hepatology, 21: 1455-1464 (1995).
Hamada et al.,J. Hepatol., 30: 807-818 (1999).
Hargus et al.,Chem. Res. Toxicol., 7: 575-582 (1994).
Koga et al.,Fukuoka Igaku Zasshi, 82: 197-206 (1991).
Kondo et al.,Cancer Res., 50: 6222-6228 (1990).
Kongo et al.,Toxicol. Lett., 105: 103-110 (1999).
Koopen et al.,Hepatology27: 537-545 (1998).
Koopen et al.,J. Lipid. Res., 40: 100-108 (1999).
Kossor et al.,Biochem. Pharmacol., 46: 2061-2066 (1993).
Kossor et al.,Fundam. Appl. Toxicol., 26: 51-62 (1995).
Kossor et al.,Toxicol. Appl. Pharmacol., 119: 108-114 (1993).
Kretz-Rommel & Boelsterli,Toxicol. Appl. Pharmacol., 120: 155-161 (1993).
Kwak et al.,Mol. Med., 7: 135-145 (2001).
Lake et al.,Toxicology., 131: 9-20 (1998).
Lake,Annu. Rev. Pharmacol. Toxicol., 35: 483-507 (1995).
Larsen & Jafcoate,Arch. Biochem. Biophys., 321: 467-476 (1995).
Laskin et al.,Hepatology, 21: 1045-1050 (1995).
Lauredo et al.,J. Appl. Physiol., 85: 2298-2304 (1998).
Lazartigues et al.Eur. J. Pharmacol., 361: 61-71 (1998).
Lee et al.,J. Pharm. Pharmacol., 52: 341-355 (2000).
Lewis et al.,Hepatology, 2: 870-873 (1982).
Liang et al.,Zhonghua Gan Zang Bing Za Zhi, 7: 72-73 (1999).
Liu et al.,Infect. Immun., 66: 5089-5098 (1998).
Liu et al.,Mol. Cell. Biol., 20: 6105-6113 (2000).
Liu et al.,Proc. Natl. Acad. Sci. U.S.A.., 98: 6192-6197 (2001).
Liu et al.,SHOCK, 14: 361-365 (2000).
Lock et al.,Toxicol. Lett., 10: 427-435 (1982).
Lorenzini et al.,Carcinogenesis, 17: 1323-1329 (1996).
Lovett,Science, 289: 536-537 (2000).
Lugovskoy et al.,Cell, 99: 747-755 (1999).
Lullmann & Lullmann-Rauch,Toxicol. Appl. Pharmacol., 61: 138-146 (1981).
Mann,Toxicol. Pathol., 25: 72-79 (1997).
Manoukian & Carson,Drug Saf., 15: 64-71 (1996).
Martelli et al.,Carcinogenesis, 16: 1265-1269 (1995).
Masubuchi et al.,J. Pharmacol. Exp. Ther., 287: 208-213 (1998).
Masubuchi et al.,J. Pharmacol. Exp. Ther., 292: 982-987 (2000).
Mayeux & Sano,N. Engl. J. Med., 341: 1670-1679 (1999).
Mayol et al.,Carcinogenesis., 13: 2381-2388 (1992).
Maziasz et al.,Toxicol. Appl. Pharmacol., 110: 365-373 (1991).
McKillop et al.,Xenobiotica., 28: 465-478 (1998).
Menegazzi et al.,Hepatology, 25: 585-592 (1997).
Metz & Ritter,J. Biol. Chem., 237: 5607-5614 (1998).
Metz et al.,Mol. Pharmacol., 58: 319-327 (2000).
Milam and Byard,Toxicol. Appl. Pharmacol., 79: 342-347 (1985).
Minamide et al.,J. Pharm. Sci., 87: 640-646 (1998).
Mitchell & Acosta,J. Toxicol. Environ. Health, 7: 83-92 (1981).
Mitchell et al.,Ann. Intern. Med., 84: 181-192 (1976).
Monteith et al.,Drug Chem. Toxicol., 19: 71-84 (1996).
Moore et al.,Fundam. Appl. Toxicol., 3: 560-568 (1983).
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