Primary biliary cirrhosis autoantigen and method of use

Details Primary biliary cirrhosis autoantigen and method of use Primary biliary cirrhosis autoantigen and method of use

1994-07-25

1999-04-06

Budens, Robert D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

4241841, 530300, 530350, A61K 3900

Patent

active

058914366

ABSTRACT:
Isolated peptides and polypeptides exhibiting the antigenicity of the 70 kD mitochondrial autoantigen of primary biliary cirrhosis are provided. The peptides, polypeptides and antigenic fragments thereof are useful in the diagnosis and treatment of primary biliary cirrhosis.

REFERENCES:
Yoon, C.K., "MS Study Yields Mixed Results," Science 259:1263, 26 Feb. 1993.
Weiner et al., "Double Blind Pilot Trial of Oral Tolerization With Myelin Antigens in Multiple Sclerosis," Science 259:1321-1324, 26 Feb. 1993.
Geysen et al., "Use of peptide synthesis to probe viral antigens for epitodes to a resolution of a single amino acid," Proc. Natl. Acad. Sci., USA 81:3998-4002, Jul. 1984.
Coppel et al. (1988) "Primary Structure of the Human M2 Mitochondrial Auto-antigen of Primary Biliary Cirrhosis: Dihydrolipoamide Acetyltransferase", Proc. Natl. Acad. Sci. USA 85, 7317-7321.
Aldesuccio et al J. Immunology vol. 137 pp. 1855-1859 (1986).
Iverson in Handbook of Experience-Immunology Edited by D.M. Wier, Blackwell Scientific Publications 1973 pp. 29.1-29.10.
Frazer et al. (1985) "Reactivity of Anti-Mitochondrial Autoantibodies in Primary Biliary Cirrhosis:Definition of two Novel Mitochondrial Polypeptide Autoantigens", The Journal of Immunology 135, 1739-1745.
Kemp et al. (1983) "Expression of Plasmodium falciparum Blood-Stage Antigens in Escherichia coli:Detection with Antibodies from Immune Humans", Proc. Natl. Acad. Sci. USA 80, 3787-3791.
Mendel-Hartvig et al.(1985) "Primary Biliary Cirrhosis:Further Biochemical and Immunological Characterization of Mitochondrial Antigens", Clin. exp. Immunol. 62, 371-379.
Stephens et al. (1983) "The Pyruvate Dehydrogenase Complex of Escherichia coli K12",J. Eur. Biochem. 133, 481-489.
Young et al. (1983) "Efficient Isolation of Genes by using Antibody Probes", Proc. Natl. Acad. Sci. USA 80, 1194-1198.

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