Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1995-02-08
1997-11-11
Smith, Lynette F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
4242081, 4242341, 4242651, 4242691, A61K 39145, A61K 3912, A61K 3900, A61K 39002
Patent
active
056860781
ABSTRACT:
Animals, including humans, are immunized by antigens, for example, the HA antigen of influenza, by first administering to a naive animal a normally strongly-immunogenic form of the antigen, for example, inactiviated or attenuated whole cell virus and subsequently administering a normally weakly-immunogenic isolated and purified viral antigen, to achieve an enhanced immune response to the purified viral antigen.
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McLaren, et al, 1980, "Comparative Antigenicity and Immunogenicity . . . " Infect. and Immunity vol. 28(1): 171-177.
Pharmaceutical Sciences, 1990, "Influenza Virus Vaccines" 1395-1397.
Butini, et al, 1994, "Comparative Analysis of HIV-Specific CTL . . . ". Abstract J306, J. Cell. Biochem Suppl. 18 B.
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Bulkovic, et al, 1987, "Immunoglobulin G Subclass . . . " Antiviral Research 8: 151-160.
Becker Robert S.
Erdile Lorne
Ferguson Laura
Harmon Maurice W.
Huebner Robert
Connaught Laboratories Inc.
Smith Lynette F.
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