Preventives/remedies for inflammatory airway diseases

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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C514S170000, C514S171000

Reexamination Certificate

active

10451061

ABSTRACT:
A preventive and/or therapeutic agent for inflammatory respiratory tract diseases containing, as an active ingredient, a steroid derivative represented by the following formula (1):(wherein R represents a hydrogen atom, a halogen atom, a hydroxy group, or —OCOR1(wherein R1represents a linear or branched alkyl group which may be substituted by a halogen atom or a cycloalkyl group; a cycloalkyl group; or an aryl group)).These compounds can continuously suppress respiratory tract inflammation and respiratory tract hyperreaction and show a high site selectivity and little systemic effect when administered directly to the respiratory tract. By virtue of these characteristics, these compounds are remarkably useful in clinical medicine as highly safe preventive and/or therapeutic agents for inflammatory respiratory tract diseases which can be administered for a long period of time.

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patent: 4655971 (1987-04-01), Page et al.
patent: 4933168 (1990-06-01), Jones et al.
patent: 5063222 (1991-11-01), Komoto et al.
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patent: 95/20393 (1995-08-01), None
Kelly and Hill, “Asthma” in Pharmacotherapy—A Pathophysiologic Approach, 2nd ed., pp. 408-449, 1992, Elsevirt Science Publishing.
Kelly, The Annals of Pharmacotherapy, 1998;32:220-232.
J. Med. Chem., vol. 34, No. 8, pp. 2468-2473, 1991.

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