Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-08-23
2011-08-23
Sznaidman, Marcos (Department: 1628)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S180000, C544S208000
Reexamination Certificate
active
08003645
ABSTRACT:
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general formula (I) below or a pharmacologically permitted salt thereof; and also to nitrogen-containing heteroaryl derivatives having specific substituents, or pharmacologically permitted salts thereof, which are valuable as preventives or remedies for Alzheimer's disease, or as amyloid protein fibril-formation inhibitors:(where, R1and R2are H or alkyl; Z1and Z2are H, alkyl, alkoxy, haloalkyl or halogeno; Z3is alkoxy, SH, alkylthio, NH2, mono- or di-alkylamino, OH or halogeno; Z4and Z5are H or halogeno; and A is 4,6-pyrimidine-1,3-diyl, 1,3,5-triazine-2,6-diyl, etc).
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Tschanz et al; “Alzheimer's: Just a memory?”,Research Matters 2006 Publication; pp. 16-19.
Kaneko Isao
Koyama Kazuo
Marumoto Shinji
Meguro Masaki
Nakagami Yasuhiro
BTG International Ltd.
Nixon & Vanderhye
Sznaidman Marcos
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