Preventive or therapeutic drug for Alzheimer's disease

Details Preventive or therapeutic drug for Alzheimer's disease Preventive or therapeutic drug for Alzheimer's disease

1997-08-04

1999-09-07

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514359, A61K 3141

Patent

active

059488000

ABSTRACT:
The present invention is directed to a drug for preventing or remedying Alzheimer's disease. The drug contains as the active ingredient 2-phenyl-1,2-benzisoselenazol-3(2H)-one (referred as compound (A)), whose effect is based on the action of reducing neuron toxicity induced by .beta.-amyloid protein.

REFERENCES:
patent: 4757063 (1988-07-01), Parnham
patent: 5246951 (1993-09-01), Galet et al.
"The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat," Dawson et al., Neuroscience Letters, 185 (1995) pp. 65-69.
"Ebselen (PZ-51) Protects the Caudate Putamen Against Hypoxia/Ischemia Induced Neuronal Damage," Knollema et al., Neuroscience Research Communications, vol. 19, No. 1, Jul.-Aug. 1996, pp. 47-56.
"The Role of Free Radicals in Toxicity and Disease," Sidney J. Stohs, Journal of Basic and Clinical Physiology and Pharmacology, vol. 6, No. 3-4, 1995, pp. 205-228.

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