Preventive or therapeutic agents for alzheimers disease a screen

Details Preventive or therapeutic agents for alzheimers disease a screen Preventive or therapeutic agents for alzheimers disease a screen

1996-02-20

1998-11-17

Leguyader, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 2431, 435 6, 435 911, 435353, C07H 2102, C07H 2104

Patent

active

058378537

ABSTRACT:
A preventive or therapeutic agent for Alzheimer's disease which comprises a substance exhibiting an inhibitory action to tau-protein kinase I as an effective component is provided. A pharmaceutical composition comprising said agent and a method of inhibiting neuronal cell death in the brain are also provided.

REFERENCES:
A. Caceres et al., "The effect of Tau Antisense Oligonucleotides on Neurite Formation of Cultured Cerebellar Macroneurons", The Journal of Neuroscience, vol. 11, No. 6, pp. 1515-1523, Jun. 11, 1991.
K. Ishiguro et al., "Tau Protein Kinase I Converts Normal Tau Protein into A68-like Component of Paired Helical Filaments", The Journal of Biological Chemistry, vol. 267, No. 15, pp. 10897-10901, May 25, 1992.
K. Ishiguro et al., "Phosphorylation Sites on Tau by Tau Protein Kinase I, A Bovine Derived Kinase Generating an Epitope of Paired Helical Filaments", Neuroscience Letters, vol. 148, No. 1 and 2, pp. 202-206, Dec. 14, 1992.
A. Takashima et al., "Tau Protein Kinase I is Essential for Amyloid .beta.-Protein-Induced Nerotoxicity", Proc. Natl. Acad. Sci., vol. 90, No. 16, pp. 7789-7793, Aug. 15, 1993.
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Weiss (1991) Science News 139, 108-109.
Woodgett (1990) EMBO J. 9, 2431-2438.
Alma et al (1991) Drugs Exptl. Clin. Res. XVII, 575-579.
Ishiguro et al (1993) FEBS Lett 325, 167-172.
Bramblett et al (1992) Lab. Invest. 66, 212-222.

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