Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from plantago
Reexamination Certificate
2002-04-22
2004-11-02
Flood, Michele (Department: 1654)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from plantago
C424S758000, C424S764000, C424S776000, C424S778000, C424S439000, C514S826000
Reexamination Certificate
active
06811796
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is a preventive or therapeutic agent for pollen allergy, allergic rhinitis, atopicdermatitis, asthma or urticaria or a health food for prevention, improvement or reduction of symptoms thereof.
2. Description of the Related Art
In recent years, there has been a rapid increase in the number(s) of patients suffering from allergies caused by cedar pollen and by plants such as
Ambrosia artemisiifolia, Dactylis glomereta
, Phleumpratanse, and birch or their pollen. In pollen allergies, chemical transmitters such as histamine and leukotriene and various enzymes are liberated from mast cells and basophils by pollen entering the body, and the typical symptoms of allergic conjunctivitis and allergic rhinitis (such as sniffles, stuffiness and sneezing) thereby appear, particularly in the nose and eyes.
There has been also an increase in allergic rhinitis, atopic dermatitis, asthma, urticaria, etc., caused not only by pollen, but also by house dust, ticks, etc., carrying allergens.
As a therapeutic countermeasure therefore, preventive therapy by anti-allergic agents has been carried out. This has consisted of a symptomatic treatment by new generation antihistaminic agents having fewer side effects on the nerves etc., orally administered agents such as various antagonists to chemical transmitters and inhibitors of the liberation of chemical transmitters, steroidal agents having a rapid pharmaceutical effect, and antihistaminic nasal drops having immediate effect and strong action, as well an hyposensitizing therapy: etc. However, traditional Chinese drugs or antiallergic agents having a satisfactory effect in preventive therapy have yet to be found. In addition, with regard to antihistaminic agents and steroidal preparations, which are used in symptomatic treatment, their side effects often cause problems. In terms of therapy, it has been also reported that the degree of patients' satisfaction with the current status of treatment is extremely low. On the other hand, hyposensitizing therapy, while considered adequate by some, is beginning to show its limitations.
In U.S. Pat. No. 5,882,672, it is reported that when the seeds of one or more (preferably both) of the genera
Cucurbita moschata
and
Plantago asistica
, and the flowers of
Lonicera japonica
are added to feed, natural infections by parasites, bacteria and viral diseases are largely prevented, the prophylactic force of living bodies is enhanced, and the flesh and ooplasm are improved. A feed in which two kinds of crude drugs composed of seeds, those of
Cucurbita moschata
and
Plantago asiatica
, and two kinds of crude drugs composed of flowers, those of
Lonicera japonica
and
Carthamus tinctorius
, were combined, was given to chickens to improve the quality of their eggs. Moreover, better heath and survival rates, improvement in ooplasm and anti-leucocytozoonosis were observed. Further, in quail, the suppression of anti-Newcastle disease and enteric coccidium and a reduction in the incidence of the number of Staphylococci were also observed.
In U.S. Pat. No. 4,421,746, it is stated that an interferon inducer can be extracted from the plants of the genus Cucurbitaceae, such as Japanese pumpkin and, in U.S. Pat. No. 4,456,597, antiviral activity and anti-tumor activity of interferon inducers extracted from
Carthamus tinctorius
were also reported, leading to the conclusion that the inducer is useful as an anti-tumor agent and agent for the improvement of physiological action and general enhancement of health. In addition, in U.S. Pat. No. 4,469,685, it is reported that interferon inducers may be extracted from the flowers of
Lonicera japonica
, seeds of
Plantago asiatica
, etc., and are useful for the prevention of, and therapy, for viral infections in human beings and animals. In Japanese Patent Laid-Open No. 116,498/1999, a macrophage activator is described in which two crude drugs—seeds of
Cucurbita moschata
and flowers of
Carthamus tinctorius—
are combined and, in Japanese Patent Laid-Open No. 281,584/2000, a neutrophil activator wherein four kinds of crude drugs—seeds of
Cucurbita moschata
, flowers of
Carthamus tinctorius
, seeds or total plant of
Plantago asiatica
, and flowers of
Carthamus tinctorius
and
Lonicera japonica
—are combined, is described.
SUMMARY OF THE INVENTION
The present inventors have carried out an intensive investigation with the object of finding further specific uses of crude drugs such as the seeds of
Cucurbita moschata
and
Plantago asiatica
, and the flowers of
Carthamus tinctorius
and
Lonicera japonica
, etc., having such excellent effects as mentioned above. As a result, it has bean found that a combination of two kinds of crude drugs—seeds of
Cucurbita moschata
and flowers of
Carthamus tinctorius
—with at least one crude drug selected from
Plantago asiatica, Lonicera japonica, Glyoyrrhiza uralensis, Coixlachryma
-
jobi
var.
ma
-
yuen, Zingiber officinale, Curcuma longa, Curcuma zedoaria, Artemisia argyi
, etc., (particularly a combination of four crude drugs—seeds of
Cucurbita moschata
and
Plantago asiatica
, and flowers of
Carthamus tinctorius
and
Lonicera japonica
—or a combination of
Perilla frutescens
var.
crispa
with a combination of three crude drugs—seeds of
Cucurbita moschata
, flowers of
Carthamus tinctorius
and cereal of
Coix lachrymal
-
jobi
var.
ma
-
yuen
), have had excellent effects in the prevention of, or therapy for pollen allergy, allergic rhinitis, atopic dermatitis, asthma or urticaria. In addition, it is also very safe.
Thus, the present invention is a preventive or therapeutic agent for pollen allergy, allergic rhinitis, atopic dermatitis, asthma or urticaria, containing two kinds of crude drugs—seeds of
Cucurbita moschata
and flowers of
Carthamus tinctorius
—and at least one crude drug selected from
Plantago asiatica, Lonicera japonica, Glycyrrhiza uralensis, Coix lachrymal
-
jobi
var.
ma
-
yuen, Zingiber officinale, Curcuma longa, Curcuma zedoaria
and
Artemisia argyi
, as effective components. The present invention is also a preventive or therapeutic agent for pollen allergy, allergic rhinitis, atopic dermatitis, asthma or urticaria, containing four kinds of crude drugs—seeds of
Cucurbita moschata
and
Plantago asistica
, and flowers of
Carthamus tinctorius
and
Lonicera japonica
—as effective components, or is a preventive or therapeutic agent for pollen allergy, allergic rhinitis, atopic dermatitis, asthma or urticaria, containing four kinds of crude drugs—seeds of
Cucurbita moschata
, flowers of
Carthamus tinctorius
, cereal of
Coix lachrymal
-
jobi
var.
ma
-
yuen
and leaves of
Perillafrutescens
var.
crispa
—as effective components.
Further, the present invention is a method for the prevention of, or therapy for, pollen allergy, allergic rhinitis, atopic dermatitis, asthma or urticaria by administration of two kinds of crude drugs—seeds of
Cucurbita moschata
and flowers of
Carthamus tinctorius
—and at least one crude drug selected from
Plantago asiatica, Lonicera japonica, Glycyrrhiza uralensis, Coix lachrymal
-
jobi
var.
ma
-
yuen, Zingiber officinale, Curcuma longa, Curcuma zedoaria
and
Artemisia argyi
, to patients. The present invention is also a method for the prevention of, or therapy for pollen allergy, allergic rhinitis, atopic dermatitis, asthma or urticaria by administration of four kinds of crude drugs—seeds of
Cucurbita moschata
and
Plantago asiatica
, and flowers of
Carthamus tinctorius
and
Lonicera japonica
—to patients or is a method for the prevention of or therapy for, pollen allergy, allergic rhinitis, atopic dermatitis, asthma or urticaria by the administration of four kinds of crude drugs—seeds of
Cucurbita moschata
, flowers of
Carthamus tinctorius
, cereal of
Coix lachrymal
-
jobi
var.
ma
-
yuen
and leaves of
Perilla frutescens
var.
crispa
—to patients.
Furthermore, the present invention is a method for the prevention of pollen allergy by the administration of two kinds of crude dr
Finnegan Henderson Farabow Garrett & Dunner LLP
Flood Michele
Matsuura Yakugyo Co., Ltd.
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