Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Casein or caseinate
Patent
1996-10-11
1997-12-30
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Casein or caseinate
530407, 530343, 530361, 514 21, 405 681, A61K 3764, A61K 3520, A61K 3716
Patent
active
057032122
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a preventive for circulatory diseases which has the effect for the prevention of circulatory diseases, particularly cerebral stroke.
BACKGROUND OF THE INVENTION
With the recent changes in eating habits and advances in medical technology, the incidence of adults' diseases including hypertension and hyperlipemia is on the steady increase. There is a mounting interest in preventive medicine today in the face of changes in the social environment and functional substances qualified for both safety and prophylactic efficacy are gathering attention or being sought. Today the world population is leaning more and more on the higher end of the age scale, and it is the most important mission of those concerned with medical care and medical science to establish a perspective for "healthy longevity".
Model animals for diseases participated in the blood vessel which are crucial factors in human aging, namely for such diseases as circulatory diseases represented by cerebral stroke (Yamori Y. et al. Jpn. Circ. J., 38, 1095, 1974), myocardial infarction (Yamori Y. et al, Atherosclerosis, 42, 15, 1982), arteriosclerosis, multi-infarct dementia, etc., have been developed and it has been demonstrated by using such models that even in the presence of hereditary dispositions, circulatory diseases can be prevented by the proper nutrition. According to experiments using model animals, namely SHR (spontaneously hypertensive rats) (Okamoto K., et al, Jpn. Circ. J., 27, 282, 1963) and SHRSP (stroke-prone SHR), excess intake of sodium chloride encourages these diseases, while certain nutrients in food prevent them. For example, it has been shown that when soybean protein, lysine, taurine, potassium, calcium, magnesium, palmitoleic acid, etc. are administered before onset of hypertension or in an early stage after onset and onwards, they show prophylactic effects on this disease (Yamori Y., et al., New horizon in preventing cardiovascular diseases, Yamori Y. and Strasser T. eds., Elsevier, Amesterdam, pp. 1, 1989).
The factors occurring in food have also been explored and scrutinized and it has become increasingly clear that substances derived from food proteins can play a variety of physiological roles. Development of food materials having relevant activities to adults' diseases, i.e. blood cholesterol-lowering activity and antihypertensive activity (Karaki H., et al., Comp. Biochem. Physiol., 96C, 367, 1990), has been undertaken with great enthusiasm and many substances have been made available commercially as materials for performance foods (nutraceutical foods or functional foods) and foods for specified health use.
Recently, it has been reported that the ACE inhibitor, or captopril inhibits the onset of stroke in the SHRSP at a low dose just of being short of causing hypotension (Ohta Y., et al., Genetic. Hypertens., 218, 393, 1992). However, captopril has adverse side effects such as skin rush, and other substances known to be effective for circulatory diseases, particularly cerebral stroke, are objective for symptomatic treatment with undesirable adverse reactions such as blood-pressure fluctuation and so on.
Therefore, from the standpoint of preventive medicine, there has been a great standing need for substances which are highly safe, free from side effects such as blood-pressure fluctuation, prophylactively effective for the onset of circulatory diseases, particularly cerebral stroke, and inexpensive enough for daily consumption.
DISCLOSURE OF THE INVENTION
The present invention has for its object to provide a prophylactic composition for circulatory diseases which is free from adverse side effects such as blood-pressure fluctuation and effective in the prevention of circulatory diseases, inclusive of cerebral stroke in particular.
The inventors of the present invention explored a variety of foodstuffs in search for substances which would be prophylactively effective for circulatory diseases, particularly cerebral stroke, and found that a low-molecular-weight peptide fr
REFERENCES:
patent: 4161520 (1979-07-01), Osborne et al.
patent: 4361564 (1982-11-01), Edwards
patent: 5037957 (1991-08-01), Grubb et al.
Murakami Umeji
Sugai Ryuji
Yamori Yukio
Kanebo Ltd.
Touzeau P. Lynn
Tsang Cecilia J.
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