Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
1999-12-06
2001-08-07
Cook, Rebecca (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C514S880000, C424S663000
Reexamination Certificate
active
06271260
ABSTRACT:
TECHNICAL FIELD
The present invention relates to a composition and method for the retardation or prevention of hair growth.
BACKGROUND ART
In the past, there has been great emphasis on methods and compositions relating to the inhibition of unwanted hair growth in humans. In particular, for cosmetic reasons it is desirable to remove unwanted hair from parts of the body such as the legs, armpits and face without recourse to shaving.
The products that are currently available for topical use in the removal of unwanted hair are mostly based on thioglycollates as the active ingredient. Examples of products containing thioglycollates are available under the trade names “VEET” and “NAIR”. Thioglycollates function as reducing agents at high pH by reducing disulfide bonds in hair. Following penetration into the follicular canal. the hair is weakened in the region above the keratinizing zone. The hair shaft may then be broken off just below the skin surface leaving a soft, smooth skin surface.
Hair growth does not however cease and, since the hair is broken near the surface, regrowth occurs within a relatively short time and the cosmetic advantage is thus rapidly lost. Retreatment with the thioglycollate product is necessary if the treated skin is to be maintained in a hairless condition. There is consumer resistance to the continual use of thioglycollate hair removal product as skill irritation is sometimes encountered. However, as no alternative methods of hair removal exist apart from shaving and plucking (including the use of tweezers, forceps and waxing) of individual hairs, in the past thioglycollate-containing products have offered the most effective method. particularly for women, for the removal of unwanted hair from the body surface.
The present inventors have surprisingly found a method and a composition which when applied topically to the skin retards or prevents hair growth. The inventors have found that the method and composition cause the hair growth to be finer, thinner, shorter and much less visible. Typically, coarse hair is replaced by vellus hair. With repeated application the inventors of the present invention have found that hair growth may be prevented entirely.
DISCLOSURE OF INVENTION
In a first aspect, the present invention consists in a composition for retarding or preventing hair growth including:
(a) citric acid:
(b) an electrolyte; and
(c) a cosmetically acceptable aqueous vehicle which includes a film forming agent.
In a second aspect, the present invention consists in a method for retarding and/or preventing hair growth comprising applying a composition which includes:
(a) citric acid;
(b) an electrolyte; and
(c) a cosmetically acceptable aqueous vehicle which includes a film forming agent;
to an area of skin in which hair growth occurs and allowing the composition to contact the skin for a time sufficient so as to effectively prevent or retard hair growth.
In a third aspect. the present invention is directed to the use of a composition as defined in the first aspect of the invention for preventing or retarding hair growth.
The concentration of citric acid may be greater than 30% w/w. Preferably, the concentration of citric acid will be in the range of 1 to 30% w/w and more preferably 5 to 20% w/w.
The electrolyte may be selected from a variety of compounds including alkali metal and alkali earth metal salts that are water soluble. Preferably the electrolyte is sodium chloride and more preferably Dead Sea Salt. The electrolyte may be present in a concentration of greater than 20% w/w. Preferred concentrations of electrolyte are in the range of 1 to 20% w/w and more preferably 5 to 10% w/w.
The cosmetically acceptable aqueous vehicle acts as a diluent, dispersant or carrier for other materials present in the composition, so as to facilitate the distribution of the composition when applied to the relevant area of skin. Suitable vehicles include emulsions, microemulsions or an aqueous solution or dispersion of a film forming agent.
The film forming agent may be selected from a variety of ingredients including liquid or solid emollients, emulsifiers, surface active agents, gums, humectants, thickeners, powders and protein solutions. These agents can be used singly or as mixtures of one or more agents. Preferably the film forming agent is present in a concentration in the range of 0.05 to 40% w/w.
Emollients, such as mineral oil, fatty alcohols, alkyl esters, silicones and silicone derivatives may be employed in the present invention. Fatty alcohols may be selected from stearyl alcohol and cetyl alcohol. Alkyl esters may be selected from octyl palmitate, decyl oleate and isopropyl myristate. Silicones and silicone derivatives may be selected from phenyl dimethicone, dimethicone and simethicone. It will be appreciated, however, that the present invention is not limited to the aforementioned emollients.
The composition of the present invention may optionally comprise one or more emulsifiers/surface active agents, the choice of which will normally determine whether a water-in-oil emulsion or an oil-in-water emulsion is formed. Emulsions preferably contain 3.0 to 10% w/w of emulsifiers and more preferably 0.5 to 15% w/w. Microemulsions preferably contain 0.5 to 35% w/w of surface active agents and more preferably 15 to 28% w/w.
Emulsifiers, such as mixtures of glyceryl stearate and PEG-100 stearate (Lipomulse 165 and Arlacel 165), Tegocare PS (methyl glucose sesquistearate), PEG7 hydrogenated castor oil (Arlacel 989) and glyceryl sorbitan oleostearate (Arlacel 481) can be employed in the present invention. It will be appreciated, however, that the present invention is not limited to the aforementioned emulsifiers.
Surface active agents for microemulsions may be selected from Lipocol SC20 (Ceteareth-20), Ameroxol OE20 (Oleth-20), Lipocol L4 (Laureth-4), Amerchol L101 (Lanolin alcohol and mineral oil), Cetiol HE (PEG 7 glyceryl cocoate) and Liponic EG1 (Glycereth-20). It will be appreciated, however, that the present invention is not limited to the aforementioned surface active agents.
The composition of the present invention may be preserved by humectants which act as water activity depressants. Humectants such as glycerol and polylethylene glycols may be employed in the present invention. Preferably, the humectant is present in a concentration of between 1 to 5% w/w. It will be appreciated, however, that the present invention is not limited to the aforementioned humectants.
A variety of gums including Sclerotium gum (Amigel) may be used in the present invention. Amigel is an effective polymer film forming agent and is preferably present in a concentration of 0.1 to 2% w/w.
Powders such as clays, silicas, talc and starch may be employed in the present invention. A variety of clays may be used including bentone. Silicas are preferably fumed silicas.
A variety of protein solutions may be used including beer.
It will be appreciated, however, that the present invention is not limited to the aforementioned electrolytes and film forming agents.
The composition according to the present invention may optionally comprise one or more conventional antiperspirant or deodorant active substances. Compositions according to the present invention can thus be used regularly on the underarm not only to prevent unwanted hair growth but also to reduce or eliminate perspiration and/or to reduce or eliminate malodour. Examples of conventional antiperspirant actives include astringent metallic salts such as aluminium chloride, aluminium chlorohydrate and zirconium chlorohydrate. A suitable deodorant is triclosan (Irgasan DP 300).
The pH of the composition of the present invention is preferably below 4.
The composition of the present invention may take the form of a cream, lotion, gel or spray.
The composition of the present invention may be topically applied to a selected area of the body in which it is desired to inhibit hair growth. For example, the composition can be applied to the face, neck, upper lip, chin, legs, arms, torso and armpits.
According to the method of the present inventi
Kahale Laura
Nearn Malcolm
Cook Rebecca
Gifford, Krass, Groh Sprinkle, Anderson & Citkowski, P.C.
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