Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1994-05-26
1998-12-01
Crouch, Deborah
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435348, 935 70, C12N 1500, C12N 500
Patent
active
058437363
ABSTRACT:
Disclosed is a new, effective and general methodology to prevent viral infection, which methodology is divided into two parts: 1) induction of the apoptosis (programmed cell death) of a host upon viral infection to block viral reproduction; and 2) the use of an apoptosis triggering gene, the persistency-associated gene 1 (pag1, now renamed as hem1 in light of the position thereof in the restriction map of the Hz-1 viral genome) to prevent the viral infection.
REFERENCES:
Clem et al (1993) J. Virol. 67, 3730-3738.
Clem et al (1994) J. Virol. 68, 6759-6762.
Rabizadeh et al (1993) J. Neurochem. 61, 2318-2321.
Bump et al (1995) Science 269, 1885-1888.
Yu et al (1995) Proced. Nat. Acad. Sci. 92, 699-703.
Leavitt et (1994) Human Gene Therapy 5, 1115-1120.
Leib, et al. "A Deletion Mutant of the Latency-Associated Transcript of Herpes Simplex Virus . . .", Journal of Virology, pp. 2893-2900, Jul. 1989.
Halstead "Dengue haemorrhagic fever-a public health problem and a field for research", Bulletin of the WHO, 59:1-21, 1980.
Halstead "Selective Primary Health Care: Strategies for Control of Disease in the Developing World", Rev. of Infect. Diseases, 6,2: 251-264, 1984.
Klein "Are Invertebrates Capable of Anticipatory Immune Responses?", Scand. J. Immunol., 29:499-505, 1989.
Tomei, et al. "Introduction", Apoptosis: The Molecular Basis of Cell Death, pp. 1-3, 1991.
Steller, et al. "A transposable P vector that confers electable G418 resistance to Drosophila larvae", The EMBO Journal, 4,1: 167-171, 1985.
Kerr, et al. "Definition and Incidence of Apoptosis: An Historical Perspective", Apoptosis: The Molecular Basis of Cell Death, pp. 5-29, 1991.
Granados, et al. "An Insect Cell Line Persistently Infected with a Baculovirus-Like Particle", Intervirology, 10: 309-317, 1978.
Ralston, et al. "Cell Culture Studies with the IMC-Hz-1 Nonoccluded Virus.sup.1 ", Virology, 115: 33-44, 1981.
Wood, et al. "Persistent and Productive Infections with the Hz-1 Baculovirus", Current Topics in Microbiology and Immunology, 131: 119-133.
Burand, et al. "Persistent Baculovirus Infections", The Biology of Baculoviruses, 1: 159-175.
Burand, et al. "Defective Particles from a Persistent Baculovirus Infection in Trichoplusia ni Tissue Culture Cells", Jnl. of Gen. Virology, 64: 391-398 (1983).
Burand, et al. "Intracellular Protein Synthesis During Standard and Defective Hz-1 Virus Replication", Jnl. of Gen. Virology, 67: 167-173.
Huang, et al. "Characterization of the DNA of a Nonoccluded Baculovirus, Hz-1V", Journal of Virology, pp. 174-181, Jul., 1982.
Burand, et al. "Structural and Intracellular Proteins of the Nonoccluded Baculovirus Hz-1", Journal of Virology, pp. 137-142, Apr., 1983.
Whitaker-Dowling, et al. "Superinfection Exclusion by Vesicular Stomatitis Virus", Virology, 131: 137-143, 1983.
Chao, et al. "Physical Map of Hz-1 baculovirus genome from standard and defective interfering particles", Jnl. of Gen. Virology, 71: 1265-1270, 1990.
Chao, et al. "Differential Expression of Hz-1 Baculovirus Genes during Productive and Persistent Viral Infection", Jnl. of Gen. Virology, pp. 1442-1448, Mar., 1992.
Oldstone "Viral Persistence", Cell, 56: 517-520, 1989.
Spivack, et al. "Expression of Herpes Simplex Virus Type 1 Latency-Associated Transcripts in the Trigeminal . . . ", Journal of Virology, pp. 1479-1485, May, 1988.
Stevens, et al. "RNA Complementary to a Herpesvirus .alpha. Gene mRNA is Prominent in Latently Infected Neurons", Science Reports, 2: 1056-1059, 1987.
Vaughn, et al. "The Establishment Of Two Cell Lines From The Insect Spodoptera Frugiperda (Lepodoptera: Noctuidae)", In Vitro, 13,4: 213-217, 1977.
Wood "Protease Degradation of Autographa californica Nuclear Polyhedrosis Virus proteins", Virology, 103: 392-399, 1980.
Clem, et al. "Prevention of Apoptosis by a Baculovirus Gene During Infection of Insect Cells", Science Reports, 254: 1388-1390, 1991.
Chen "Flourescent Labeling of Mitochondria", Methods in Cell Biology, pp. 103-123, 1989.
Gregory, et al. "Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis", Letters to Nature, 349: 612-617, 1991.
Wilson "Properties of the Virus Particle", Classification and Nomenclature of Viruses, pp. 117-123.
Martz, et al. "CTL: virus control cells first and cytolytic cells second?", Immunology Today, 10,3: 79-86, 1989.
Henikoff "Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing", Gene, 28: 351-359, 1984.
Lawler, et al. "The Structure of Human Thrombospondin, an Adhesive Glycoprotein with . . . ", Jnl. of Cell Biology, 103: 1635-1648, 1986.
Sanger, et al. "DNA sequencing with chain-terminating inhibitors", Proc. Natl. Acad. Sci., 74,12: 5463-5467, 1977.
Chen, et al. "Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA", DNA, 4,2: 165-170, 1985.
Tabor, et al. "DNA sequence analysis with a modified bacteriophage T7 DNA polymerase", Proc. Natl. Acad. Sci., 84: 4767-4771, 1987.
Chao, et al. "Investigate The Nature Of Viral Persistent Infections Using Hz-1 Baculovirus As A Model System", Mol. Ent. Symp., pp. 33-47, Jul., 1990.
Aubusel, et al. "Preparation and Analysis of RNA", Current Protocols In Molecular Biologypp. 4.0.1-4.2.2, 1988.
Stephenson, et al. "Molecular analysis of the swallow gene on Drosophila melanogaster", Genes and Development, 2: 1655-1665, 1988.
Melton, et al. "Efficient in vitro synthesis of biologically active RNA and RNA . . . ", Nucleic Acids Research, 12, 18: 7035-7056, 1984.
Fickett "Recognition of protein coding regions in DNA sequences", Nucleic Acids Research, 10,17: 5303-5318, 1982.
Zuker, et al. "Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information", Nucleic Acids Research, 9,1: 133-148, 1981.
Freier, et al. "Improved free-energy parameters for predictions of RNA duplex stability", Proc. Natl. Acad. Sci., 83: 9373-9377, 1986.
Spivack, et al. "Detection of Herpes Simplex Virus Type 1 Transcripts during Latent Infection in Mice", Journal of Virology, pp. 3841-3847, Dec., 1987.
Steiner, et al. "Herpes simplex virus type 1 latency-associated transcripts re evidently not essential . . . ", The EMBO Journal, 8,2: 505-511, 1989.
Ho, et al. "Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse", Proc. Natl. Acad. Sci., 86: 7596-7600, 1989.
Block, et al. "A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant Reactivates . . . ", Journal of Virology, pp. 3417-3426, Jul., 1990.
Zwaagstra, et al. "Activity of Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Promoter in Neuron-Derived Cells . . .", Journal of Virology, pp. 5019-5028, Oct., 1990.
Sharp, et al. "HIV TAR: An RNA Enhancer?", Cell, 5-: 229-230, 1989.
Brockdorff, et al. The Product of the Mouse Xist Gene Is a 17 kb Inactive X-Specific Transcript Containing . . . , 71: 515-526, 1992.
Brown, et al. "The Human Xist Gene: Analysis of a 17 kb Inactive X-Specific RNA That Contains . . . ", Call, 71: 527-542, 1992.
Lee, et al. "Pulse-Labeled Ribonucleic Acid Complexes Released by Dissociation of Rat Liver Polysomes", Biochemistry, 10,3: 510-517, 1971.
Brockdorff, et al. "Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome", Letters to Nature, 351: 329-331, 1991.
Brown, et al. "A gene from the region of the human X inactivation centre is expressed exclusively from . . . ", Nature, 349: 38-44, 1991.
Campbell, et al. "Identification of Herpes Simplex Virus DNA Sequences Which Encode a Trans-acting Polypeptide . . . ", J. Mol. Biol., 180: 1-19, 1984.
Steiner, et al. "A Herpes Simplex Virus Type 1 Mutant Containing a Nontransinducing Vmw65 Protein . . . ", Journal of Virology, pp. 1630-1638, Apr., 1990.
Weinheimer, et al. "Deletion of the VP16 Open Reading Frame of Herpes Simplex Virus Type 1", Journal of Virology, pp. 258-269, Jan., 1992.
Rooney, et al. "Genome rearrangements activate the Epstein-Barr virus gene whose product disrupts latency", Proc. Natl. Acad. Sci., 85: 9801-9805, 1988.
Flemington, et al. "Autoregulation of Epstein-Barr Virus Putati
Crouch Deborah
National Science Council of R.O.C.
LandOfFree
Prevention of viral infection by the induction of apoptosis and/ does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Prevention of viral infection by the induction of apoptosis and/, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prevention of viral infection by the induction of apoptosis and/ will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2395026