Prevention of prosthesis calcification

Details Prevention of prosthesis calcification Prevention of prosthesis calcification

1989-01-27

1990-12-11

Cannon, Alan W.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

623 1, 623 2, 623 3, 623 66, 523113, 427 2, 427417, 8 9411, 8 9420, A61F 202, A61F 206, A61F 222, A61F 224

Patent

active

049767330

ABSTRACT:
A method for retarding or preventing the calcification of a prosthesis implanted in a mammal by covalently coupling to the prosthesis before implantation an effective amount of an anticalcification agent in the form of an aliphatic carboxylic acid, or a derivative thereof, which contains from about 8 to about 30 carbon atoms and which may be straight-chain or branched-chain and saturated or unsaturated. Such acid is substituted by at least one amino, mercapto, carboxyl or hydroxyl group by which the covalent coupling takes place. For a natural tissue prosthesis, such coupling may be to an aldehyde group of gluteraldehyde in which the tissue is pre-soaked.

REFERENCES:
patent: 4553974 (1985-11-01), Dewanjee
patent: 4831065 (1989-05-01), Pietsch et al.

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