Prevention of N-nitroso compound formation in vivo

Details Prevention of N-nitroso compound formation in vivo Prevention of N-nitroso compound formation in vivo

1986-06-26

1987-07-21

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

514458, 514474, 424464, A61K 922, A61K 31555, A61K 3134

Patent

active

046817565

ABSTRACT:
The effect of a controlled release, hydrodynamically balanced dosage formulation containing both an aqueous phase N-nitroso compound blocking agent and a lipid phase N-nitroso compound blocking agent in preventing the formation of nitrosamines and nitrosamides in the stomach is disclosed.

REFERENCES:
Physicians' Desk Ref. Non Prec. Drugs, p. 601, 1982.
Ramm et al., Tox. and App. Pharm., 41:575-583, 1977.
Ohshima et al., Can. Res., 41:3658, 1981.

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