Prevention of mammary carcinoma

Details Prevention of mammary carcinoma Prevention of mammary carcinoma

1988-09-30

1990-06-26

Lipovsky, Joseph A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514182, A61K 3156

Patent

active

049372386

ABSTRACT:
To reduce the risk of breast cancer, a drug is periodically administered to young mammals before pregnancy in doses of about 1 microgram to 50 micrograms per kilogram of body weight. The drug: (1) competes with and displaces estradiol 17 beta from the mammary gland cells in an effective manner to prevent the possible formation of DNA-damaging epoxide estradiol metabolites; (2) binds to breast tissue to a greater extent than estradiol 17 beta; (3) induces terminal nonlactation differentiation of the mammary gland; (4) is nontoxic and noncarcinogenic; and (5) preferably does not cause anti-ovulatory activity. The drug is selected from a group of drugs including: (1) 4-OH estradiol; (2) d-equilenin; and (3) 17 alpha ethynyl estriol.

REFERENCES:
patent: 3868452 (1975-02-01), Kraay et al.
The Merck Index; 10th Ed. (1983); #3579, Equilenin.
Chemical Abstracts; vol. 100 (1984) #186065M; Dehennin et al.
Chemical Abstracts; vol. 101 (1984) #488096; Leclercq et al.
Chemical Abstracts; vol. 101 (1984) #48830b; Katzenellenbogen.

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