Prevention of leakage and phase separation during thermotropic p

Details Prevention of leakage and phase separation during thermotropic p Prevention of leakage and phase separation during thermotropic p

1996-12-17

1999-02-09

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

A61K 9127

Patent

active

058690921

ABSTRACT:
Leakage from liposomes or biological cells and structural damage, which occur upon cooling through the thermotropic phase transition temperature and upon storage at temperatures below the phase transition temperature are reduced or eliminated by incorporating thermal hysteresis proteins in the liposome or cell structure. Preferred thermal hysteresis proteins are antifreeze proteins and antifreeze glycoproteins from polar fish species, and chromatographic fraction no. 8 of antifreeze glycoproteins has been found to be particularly effective.

REFERENCES:
patent: 5118792 (1992-06-01), Warren et al.
patent: 5173219 (1992-12-01), Kim
patent: 5225182 (1993-07-01), Sharma
patent: 5358931 (1994-10-01), Rubinsky et al.
M.J. Poznansky, et al., "Biological Approaches to the Controlled Delivery of Drugs: A Critical Review," Pharmacological Reviews 36(4): 277-335 (1984).

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