Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-06-07
1998-04-14
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530412, 536 237, C07K 1400, C07K 1436
Patent
active
057392838
ABSTRACT:
A new, non-toxic pharmaceutical composition for the treatment and prevention of invasive pulmonary aspergillosis has been discovered. The new pharmaceutical composition includes a physiologically compatible carrier and an agent which inhibits the proteolytic activity of the extracellular elastolytic serine protease produced by aspergillus. The agent preferably comprises a serine protease inhibitor, more preferably a subtilisn-type inhibitor, most preferably streptomyces subtilisin inhibitor. Such pharmaceutical compositions are effective at reducing the incidence of mortality due to invasive pulmonary aspergillosis and are also effective at reducing the invasion of lung tissue and the tissues surrounding the lungs by the germinating hyphae of Aspergillus. The invention also relates to a method of treating invasive pulmonary aspergillosis using a pharmaceutical composition comprising a serine protease inhibitor, preferably a subtilisin-type inhibitor, more preferably a streptomyces subtilisin inhibitor and a physiologically compatible carrier.
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Ceselski Sarah Katherine
Copelan Edward Alan
Kolattukudy Pappachan E.
Markaryan Adam N.
Gupta Anish
The Ohio State Research Foundation
Tsang Cecilia J.
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