Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1992-09-15
1996-04-30
Azpuru, Carlos
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424464, 424484, 424489, 514770, 514771, 514970, A61K 910, A61K 914, A61K 916, A61K 920
Patent
active
055123007
ABSTRACT:
A method for preparing ibuprofen granulations which exhibit improved stability and resistance to the formation of low melting point eutectics is disclosed. The method includes forging an amalgamation of ibuprofen and an alkali metal in a physical matrix which is suitable for inclusion in a composition without destroying the amalgamation. The stabilized ibuprofen granulation can be combined with other active ingredients and/or excipients to form compositions which have extended shelf life and are resistant to the formation of low melting point eutectics.
REFERENCES:
patent: 4145440 (1979-03-01), Fitch et al.
patent: 4610875 (1986-09-01), Panoz et al.
patent: 4753800 (1988-06-01), Mozda
patent: 4769236 (1988-09-01), Panoz et al.
patent: 4937080 (1990-06-01), Appelgren et al.
patent: 5075291 (1991-12-01), DuRoss
Kararli et al., "Solid-State Interaction of Magnesium Oxide and Ibuprofen to Form a Salt," Pharmaceutical Research, vol. 6, No. 9, 1989, 804-808.
Weng Timothy H.
Williams Michael G.
Atkins Michael J.
Azpuru Carlos
Spear James M.
Warner-Lambert & Company
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