Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1987-09-08
1989-11-14
Schofer, Joseph L.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424442, 424486, 424 78, 424422, 514619, 514617, A61K 926, A61K 31165
Patent
active
048806323
ABSTRACT:
A method, and compositions, for use in the prevention and treatment of fescue toxicosis in animals, especially cattle, sheep and horses, comprising administering to the animals a dopamine antagonist which does not cause adverse psychological or neurological effects. Useful dopamine antagonists are those specific for D.sub.2 receptors including metoclopramide, sulpiride, tiapride, alizapride and other substituted benzamides. The preferred compound is metoclopramide, a substituted benzamide having the formula 4-amino-5 chloro-N-[2-(diethylamino)ethyl]-2-methoxy benzamide monohydrochloride monohydrate. The correct dosage can be determined from the combination of the behavioral response of the animal to the compound and by measuring the serum prolactin levels over time.
In the preferred method, the compound is administered to the animals orally, using capsules, timed or slow release boluses, or as an additive in a salt, mineral, protein or energy block or animal feed, or as an implant.
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Lipham Luke B.
Stuedemann John A.
Thompson, Jr. Frederick N.
Curtis Pili
Schofer Joseph L.
The United States of America
University of Georgia Research Roundation, Inc.
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