Prevention of diabetes and prolongation of the honeymoon...

Details Prevention of diabetes and prolongation of the honeymoon... Prevention of diabetes and prolongation of the honeymoon...

2005-04-05

2005-04-05

Weber, Jon (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Lutenizing hormone releasing factor ; related peptides

C530S328000, C514S015800, C424S009100

Reexamination Certificate

active

06875843

ABSTRACT:
A method for reducing the incidence or delaying the onset of diabetes in diabetes-susceptible mammals (e.g., mice, rats, humans) is provided wherein the mammals are treated with a gonadotropin-releasing hormone (GnRH) antagonist. Additionally, the present invention provides a method of prolonging the honeymoon phase and decreasing the rate of islet cell infiltration by lymphocytes by administration of a GnRH antagonist. Preferably, the antagonist is administered repeatedly over time by subcutaneous injection. Preferred antagonists include Acetyl-β-[2-Naphthyl]-D-Ala-D-p-Chloro-Phe-β-[3-Pyridyl]-D-Ala-Ser-Nε-[Nicotinoyl]-Lys-Nε-[Nicotinoyl]-D-Lys-Leu-Nε-[Isopropyl]-Lys-Pro-D-Ala-NH2, Nal-Glu, Abarelix, Degarelix, and acetyl-D2Nal-D4CIPhe-D3Pal-Ser-Aph(Ac)-D-Aph(Ac)-Leu-Lys(lpr)-Pro-D-Ala-NH2.

REFERENCES:
patent: 5480969 (1996-01-01), Bowers et al.
Jacobson et al., Endocrinology 134, 2516-2523 (1994).*
Ansari et al., Endocrinology 145, 337-342 (2004).*
Jacobson et al., J. Allergy and Clinical Immunology 104, 653-658 (1999).*
Morale et al., Endocrinology 128, 1073-1085 (1991).*
Batticane et al., Endocrinology129, 277-286 (1991).

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