Prevention of collagenase induced disease by treatment with coll

Details Prevention of collagenase induced disease by treatment with coll Prevention of collagenase induced disease by treatment with coll

1975-12-10

1981-06-30

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424177, 424183, 424319, 424335, A61K 3514, A61K 3700, A61K 31725, A61K 31195

Patent

active

042762847

ABSTRACT:
Certain ulcers and disease conditions resulting in tissue destruction, such as those found near the cornea of the eye, and those found in the stomach, and damaged joint tissue of rheumatoid arthritis, have been found to be caused by the enzyme, collagenase. A collagenase inhibitor, such as cysteine, ethylene diamine tetraacetic acid (or sodium ethylene diamine tetraacetate), or combinations of these collagenase inhibitors, are used to treat such ulcers and to inhibit further formation thereof.

REFERENCES:
Arch. Ophthal., vol. 35, Apr. 1946, pp. 423-449; vol. 52, 1954, pp. 846-851; vol. 54 (1955) pp. 931-939.
Am. J. Ophthal. 42 527(1956); vol. 42 part II (1956), pp. 167-181.
Chemical Abstracts, vol. 71 (1969), Paragraph 68715h.

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