Prevention of atherosclerosis using NADPH oxidase inhibitors

Details Prevention of atherosclerosis using NADPH oxidase inhibitors Prevention of atherosclerosis using NADPH oxidase inhibitors

1997-05-23

1999-05-11

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

514689, 514699, 514824, A61K31/12;31/11

Patent

active

059028319

ABSTRACT:
A method for the prevention and treatment of atherosclerosis and its related diseases in mammals, in which an NADPH oxidase inhibitor is administered, is provided. The NADPH oxidase inhibitor prevents the production of reactive oxygen species upon exposure of endothelial cells to atherogenic LDL levels, thus resulting in decreased endocytosis and vascular hyperpermeability. Preferred NADPH oxidase inhibitors are of the formula: ##STR1## Additionally, there is provided a diagnostic method for predicting risk of a human patient to atherosclerotic-related diseases.

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