Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Patent
1994-09-30
1998-02-10
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
4353201, 514 44, 424 9321, C12N 700
Patent
active
057168210
ABSTRACT:
Recombinant methods for recovering wildtype or engineered negative stranded, non-segmented RNA virus genomes containing non-coding 3' and 5' regions (e.g. leader or trailer regions) surrounding one, several or all of the genes of the virus or one or more heterologous gene(s) in the form of ribonucleocapsids containing N, P and L proteins, which are capable of replicating and assembling with the remaining structural proteins to bud and form virions, or which are only capable of infecting one cell, or are defective interfering particles, are disclosed. Novel vaccines, gene therapy vectors and antiviral compounds are also disclosed.
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Rice, C
Wertz Gail W.
Yu Qingzhong
Adler Benjamin Aaron
Chambers Jasemine C.
Clark Deborah Jean Reynolds
UAB Research Foundation
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