Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-12-29
1996-10-29
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, 514 2, A61K 3800, A61K 3804, A61K 3808, A61K 3822
Patent
active
055696481
ABSTRACT:
The invention features a method of using insulin-like growth factor-I (IGF-I) or insulin-like growth factor-III (IGF-III) to prevent or treat peripheral neuropathy in a mammal.
REFERENCES:
patent: 4863902 (1989-09-01), Amagase et al.
patent: 5068224 (1991-11-01), Fryklund et al.
patent: 5420112 (1995-05-01), Lewis et al.
Guroff, G. Annals of NY Academy of Sciences, 692, 51-59 (1993) Exhibit 1 of `191.
Ekstrom et al. Ann. NY Academy of Sciences, 692:291-93, (1993); Exhibit 2 of 191.
Aizenman et al., "Brain neurons develop in a serum and glial free environment: effects of transferrin, insulin, . . . and differentiation," Brain Research 406:32-42 (1987).
Apfel et al. "Nerve Growth Factor Prevents Experimental Cisplatin Neuropathy," Ann. Neurol. 31:76-80 (1992).
Apfel et al., "Nerve Growth Factor Prevents Toxic Neuropathy in Mice," Annals of Neurology 29:87-90 (1991).
Apfel et al., "The Use of Insulin-Like Growth Factor I in the Prevention of Vincristine Neuropathy in Mice," Annals of the New York Academy of Sciences 692:243-245 (1992).
Bothwell, "Insulin and Somatemedin MSA Promote Nerve Growth FActor-Independent Neurite Formation by Cultured Chick . . . Neurons," Journal of Neuroscience Research 8:225-231 (1982).
Caroni et al., "Nerve Sprouting in Innervated Adult Skeletal Muscle Induced by Exposure to Elevated Levels of Insulin-like Growth Factors," The Journal of Cell Biology 110:1307-1317 (1990).
De Angelis et al., "Evolution of Neuropathy and Myopathy During Intensive Vincristine/Corticosteroid Chemotherapy for Non-Hodgkin's Lymphoma," Cancer 67:2241-2246 (1991).
Ekstrom et al., Annals of NY Academy of Sciences, 692:291-93 (1993).
Francis et al., "Long R.sup.3 IGF-I- A Potent Insulin-like Growth Factor-I Analog that Supports Cell Growth," Art to Science in Tissue Culture. Hyclone Laboratories Inc. 11:3, 5, 6, 7 (1992).
Guroff, G. Annals of NY Academy of Sciences 692:51-59 (1993).
Hansson et al., "Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves," Acta. Physiol. Scand. 126:609-614 (1986).
Ishii et al., "Role of Insulin, Insulin like Growth Factors, and Nerve Growth Factor in Neurite Formation," In: Insulin, IGFs and Their Receptors in the Central Nervous System, (Raizada et al., eds.) pp. 315-348 Plenum Press, New York (1987).
Legha, Sewa S., "Vincristine Neurotoxicity Pathophysiology and Management," Medical Toxicology 1:421-427 (1986).
Lewis et al., "The Potential of Insulin-like Growth Factor-I as a Therapeutic for the Treatment of Neuromuscular Disorders," Annals of the New York Academy of Sciences, 692:201-208 (1992).
Mengs et al., "Ganglioside Treatment and Nerve Regeneration: A Morphological Study After Nerve Crush in Rats," European Journal of Pharmacology 142:419-424 (1987).
Olesen et al. 1991, "Prevention and Management of Drug-Induced Peripheral Neuropathy," Drug Safety 6:302-314 (1991).
Recio-Pinto et al., "Insulin and Related Growth Factors: Effects on the Nervous System and Mechanism for Neurite Growth and Regeneration," Neurochem. Int. 12:397-414 (1988).
Ross et al., "Use of an Experimental Autoimmune Model to Define Nerve Growth Factor Dependency of Peripheral and Central Substance P-Containing Neurons in the Rat," The Journal of Neuroscience 1:1304-1311 (1981).
Shiraishi et al., "The Effect of Vincristine on Nerve Regeneration in the Rat: An Electrophysiological Study," Journal of the Neurological Sciences 71:9-17 (1985).
Apfel Stuart C.
Kessler John A.
Lewis Michael E.
Albert Einstein College of Medicine of Yeshiva University
Cephalon Inc.
Schain Howard E.
Toupau P. Lynn
LandOfFree
Prevention and treatment of peripheral neuropathy does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Prevention and treatment of peripheral neuropathy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prevention and treatment of peripheral neuropathy will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1785768